An abnormal result in one or both of these phylum suggest imbalanced normal microbes in the GI tract.
Gram-negative Bacteroidetes and grampositive Firmicutes are bacterial phyla that dominate the entire human digestive tract, including the mouth, nose, throat, and colon.
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High Firmicutes and low Bacteroidetes (resulting in a high F/B ratio) suggest microbial imbalance which may be related to:
- increased caloric extraction from food,
- fat deposition and lipogenesis,
- impaired insulin sensitivity,
- and increased inflammation.
- Poor diet
- Maldigestion or hypochlorhydria
Therapeutic Approaches & Considerations
- Balance commensal bacteria using the 5R Protocol (see this Blog article)
- When Firmicutes phyla is high, consider using Bifidobacteria probiotics and Saccharomyces boulardii primarily.
- Lactobacillus spp. and Bacillus spp. (found in probiotics) can elevate Firmicutes
- Optimize the diet; a lower fat diet may help to normalize the F/B ratio
- Address all other imbalances on the GI-MAP
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