GI-MAP by Diagnostic Solutions Diagnostic Solutions Laboratory

Virulence Factor, dupA

Optimal Result: 0 - 0.0001 Units.

→ Associated with duodenal ulcers

→ Promoting Gene A

→ Promotes inflammation

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The virulence factor dupA (duodenal ulcer-promoting gene A) is a gene associated with the bacterium Helicobacter pylori. This gene has been the subject of research to understand its role in the virulence (ability to cause disease) of H. pylori.

Research indicates that dupA may contribute to the virulence of H. pylori and its ability to cause duodenal ulcers and other gastrointestinal conditions. It has been suggested that strains of H. pylori carrying the dupA gene may have a higher prevalence in patients with duodenal ulcers, implying a potential link between dupA and the development of these ulcers. However, the exact mechanisms by which dupA influences virulence are still under investigation.

References:

Talebi Bezmin Abadi A, Perez-Perez G. Role of dupA in virulence of Helicobacter pylori. World J Gastroenterol. 2016 Dec 14;22(46):10118-10123. doi: 10.3748/wjg.v22.i46.10118. PMID: 28028359; PMCID: PMC5155170.

What does it mean if your Virulence Factor, dupA result is too high?

The virulence factor dupA is a genetic element associated with Helicobacter pylori and is thought to play a role in the bacterium's ability to cause specific gastrointestinal conditions, particularly duodenal ulcers.

Treatment considerations:

Consider the use of demulcents for mucosal protection. Demulcent, or mucilaginous, botanical medicines can be used as mucoprotection of the esophageal mucosa, both to soothe irritated tissues and promote healing.

In general all mucilage containing demulcents have the general properties of:

- Reducing irritation down the whole length of the bowel

- Reducing the sensitivity of the digestive system to gastric acids

- Helping to prevent diarrhea and reducing digestive muscle spasms

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