A healthy result should fall into the range 0.167 - 5.38 ng/mL/hr.
Renin is an enzyme produced by the kidney, especially when you are eating less salt in your diet or when your blood volume is low. It converts angiotensinogen to angiotensin I. Angiotensin 1 converts to Angiotensin II, which raises blood pressure levels. This is how your kidneys could be involved in causing high blood pressure. The Angiotensin II also stimulates your adrenal gland to produce high levels of aldosterone.
The renin plasma (blood) test is one that helps the doctor determine what is happening with your high levels of aldosterone.
Forty-six percent of people with high blood pressure don’t know why their blood pressure is high. The renin activity plasma test may help your doctor determine why your blood pressure stays high. For example, if your renin levels are high on this test, it tells your doctor that it’s possible your renal artery is closing down, a condition called renal stenosis. He can then follow up with imaging studies to confirm this.
Normal Ranges for Renin in ng/mL/hr:
0-11 months 2.000-37.000 ng/mL/hr
1 to 3 years 1.700-11.200 ng/mL/hr
4-5 years 1.000-6.500 ng/mL/hr
6-10 years 0.500-5.900 ng/mL/hr
11-15 years 0.500-3.300 ng/mL/hr
>15 years 0.167-5.380 ng/mL/hr
Sodium-depleted, upright peripheral vein specimen:
18-39 years 10.8 ng/mL/hour (mean)
2.9-24.0 ng/mL/hour (range)
40 years or older: 5.9 ng/mL/hour (mean)
2.9-10.8 ng/mL/hour (range)
Sodium-replete, upright (peripheral vein specimen)
18-39 years: 1.9 ng/mL/hour (mean)
< or =0.6-4.3 ng/mL/hour (range)
40 years or older: 1.0 ng/mL/hour (mean)
< or =0.6-3.0 ng/mL/hour (range)
Critical value: >1.5 renal venous renin ratio (This is the ratio of serum aldosterone in ng/dL to plasma renin activity in ng/mL/hr. This ratio indicates renal disease. A ratio of > or = 20 and serum aldosterone level of > or – 15 ng/dL means the condition is probably primary aldolsteronism.)
When low levels of renin are found, it may be due to any of the following reasons:
- Secondary aldosteronism
- Use of beta-blockers
- Treatment with antidiuretic hormone
- High salt diet
- Use of clonidine
- Use of non-steroidal anti-inflammatories (NSAIDs)
- Treatment with steroids that cause salt retention
- Use of alpha-methyldopa
Your doctor will possibly use additional tests to determine what is causing your high blood pressure. One of them is aldosterone levels.
Some specific causes of high renin activity might be:
- High blood pressure
- Primary aldosteronism
- Heart failure
- Liver cirrhosis and/or liver scarring
- Kidney tumors
- Renal stenosis
- Because the test was taken too early in the morning
- Restricted salt diet (<3 grams/day)
- Adrenal gland problems
- Use of diuretics
- Use of calcium channel blockers (dihydropyridine)
- Use of ACE inhibitors
- Use of angiotensin receptor antagonists
$15 per monthSelect this plan
$59 per yearSelect this plan
$250 single paymentSelect this plan
Health is not exactly rocket science. You just have to know what your body needs and doesn't need. Your medical tests contain that information. Upload them to our service and we’ll help you understand, organize, and act on them.Get Started
"I was really concerned about my lab results and my GP was not able to see me for another week. Through HealthMatters I was able to interpret my results instantly."
"I've been keeping all my lab results in a spreadsheet, covering approximately 20 years. The HealthMatters team helped me upload that info into the cloud. I can show this data to my family and doctors now easily."
"I had no idea what my lab results meant. Here I found all the biomarkers that I was looking for online. Finally, I have not only organized them all neatly in one place, but I am also grateful to be able to understand what they mean."