Renin is an enzyme produced by the kidney, especially when you are eating less salt in your diet or when your blood volume is low. It converts angiotensinogen to angiotensin I. Angiotensin 1 converts to Angiotensin II, which raises blood pressure levels. This is how your kidneys could be involved in causing high blood pressure. The Angiotensin II also stimulates your adrenal gland to produce high levels of aldosterone.
The renin plasma (blood) test is one that helps the doctor determine what is happening with your high levels of aldosterone.
Forty-six percent of people with high blood pressure don’t know why their blood pressure is high. The renin activity plasma test may help your doctor determine why your blood pressure stays high. For example, if your renin levels are high on this test, it tells your doctor that it’s possible your renal artery is closing down, a condition called renal stenosis. He can then follow up with imaging studies to confirm this.
Normal Ranges for Renin in ng/mL/hr:
0-11 months 2.000-37.000 ng/mL/hr
1 to 3 years 1.700-11.200 ng/mL/hr
4-5 years 1.000-6.500 ng/mL/hr
6-10 years 0.500-5.900 ng/mL/hr
11-15 years 0.500-3.300 ng/mL/hr
>15 years 0.167-5.380 ng/mL/hr
Sodium-depleted, upright peripheral vein specimen:
18-39 years 10.8 ng/mL/hour (mean)
2.9-24.0 ng/mL/hour (range)
40 years or older: 5.9 ng/mL/hour (mean)
2.9-10.8 ng/mL/hour (range)
Sodium-replete, upright (peripheral vein specimen)
18-39 years: 1.9 ng/mL/hour (mean)
< or =0.6-4.3 ng/mL/hour (range)
40 years or older: 1.0 ng/mL/hour (mean)
< or =0.6-3.0 ng/mL/hour (range)
Critical value: >1.5 renal venous renin ratio (This is the ratio of serum aldosterone in ng/dL to plasma renin activity in ng/mL/hr. This ratio indicates renal disease. A ratio of > or = 20 and serum aldosterone level of > or – 15 ng/dL means the condition is probably primary aldolsteronism.)
Sources:
When low levels of renin are found, it may be due to any of the following reasons:
- Secondary aldosteronism
- Use of beta-blockers
- Treatment with antidiuretic hormone
- High salt diet
- Use of clonidine
- Use of non-steroidal anti-inflammatories (NSAIDs)
- Treatment with steroids that cause salt retention
- Use of alpha-methyldopa
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
Your doctor will possibly use additional tests to determine what is causing your high blood pressure. One of them is aldosterone levels.
Some specific causes of high renin activity might be:
- High blood pressure
- Primary aldosteronism
- Hemorrhage
- Heart failure
- Liver cirrhosis and/or liver scarring
- Kidney tumors
- Renal stenosis
- Because the test was taken too early in the morning
- Restricted salt diet (<3 grams/day)
- Adrenal gland problems
- Use of diuretics
- Use of calcium channel blockers (dihydropyridine)
- Use of ACE inhibitors
- Use of angiotensin receptor antagonists
Interpret Your Lab Results
Upload your lab report and we’ll interpret and provide you with recomendations today.
Get StartedGet Started With Our Personal Plan
Advanced Plan
Unlimited Plan
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Plan
for health professionals
$45 per month
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
17-OH Progesterone, ACTH, Plasma, ADH, Aldos/Renin Ratio, Aldosterone, Anti-Mullerian Hormone (AMH), Cortisol - AM (Serum), Cortisol, Serum, Cortisol-Binding Globulin (CBG), DHEAS (Serum), Estradiol, Estradiol (male), Estradiol, Ultrasensitive, LC/MS, Estrogens, Total (female), Estrogens, Total (male), Estrone, Serum (Female), Estrone, Serum (Male), Free Cortisol, Serum, Glucagon, Growth Hormone, Human Chorionic Gonadotropin (hCG), Total, IA-2 Autoantibodies, IGF Binding Protein 1 (IGFBP 1), Leptin, Progesterone (male), Progesterone (Serum), Prolactin, Renin Activity, Plasma