Renin Activity, Plasma

Optimal Result: 0.167 - 5.38 ng/mL/hr.

Renin is an enzyme produced by the kidney, especially when you are eating less salt in your diet or when your blood volume is low. It converts angiotensinogen to angiotensin I. Angiotensin 1 converts to Angiotensin II, which raises blood pressure levels. This is how your kidneys could be involved in causing high blood pressure. The Angiotensin II also stimulates your adrenal gland to produce high levels of aldosterone. 

The renin plasma (blood) test is one that helps the doctor determine what is happening with your high levels of aldosterone.

Forty-six percent of people with high blood pressure don’t know why their blood pressure is high. The renin activity plasma test may help your doctor determine why your blood pressure stays high. For example, if your renin levels are high on this test, it tells your doctor that it’s possible your renal artery is closing down, a condition called renal stenosis. He can then follow up with imaging studies to confirm this.

Normal Ranges for Renin in ng/mL/hr:

0-11 months 2.000-37.000 ng/mL/hr

1 to 3 years 1.700-11.200 ng/mL/hr

4-5 years 1.000-6.500 ng/mL/hr

6-10 years 0.500-5.900 ng/mL/hr

11-15 years 0.500-3.300 ng/mL/hr

>15 years 0.167-5.380 ng/mL/hr

Sodium-depleted, upright peripheral vein specimen:

18-39 years 10.8 ng/mL/hour (mean)

                   2.9-24.0 ng/mL/hour (range)

40 years or older: 5.9 ng/mL/hour (mean)

                            2.9-10.8 ng/mL/hour (range)

Sodium-replete, upright (peripheral vein specimen)

18-39 years: 1.9 ng/mL/hour (mean)

                   < or =0.6-4.3 ng/mL/hour (range)

40 years or older: 1.0 ng/mL/hour (mean)

< or =0.6-3.0 ng/mL/hour (range)

Critical value:  >1.5 renal venous renin ratio  (This is the ratio of serum aldosterone in ng/dL to plasma renin activity in ng/mL/hr. This ratio indicates renal disease. A ratio of > or = 20  and serum aldosterone level of > or – 15 ng/dL means the condition is probably primary aldolsteronism.)



What does it mean if your Renin Activity, Plasma result is too low?

When low levels of renin are found, it may be due to any of the following reasons:

- Secondary aldosteronism

- Use of beta-blockers

- Treatment with antidiuretic hormone

- High salt diet

- Use of clonidine

- Use of non-steroidal anti-inflammatories (NSAIDs) 

- Treatment with steroids that cause salt retention

- Use of alpha-methyldopa

What does it mean if your Renin Activity, Plasma result is too high?

Your doctor will possibly use additional tests to determine what is causing your high blood pressure. One of them is aldosterone levels.

Some specific causes of high renin activity might be: 

- High blood pressure

- Primary aldosteronism

- Hemorrhage

- Heart failure

- Liver cirrhosis and/or liver scarring

- Kidney tumors

- Renal stenosis

- Because the test was taken too early in the morning

- Restricted salt diet (<3 grams/day) 

- Adrenal gland problems

- Use of diuretics 

- Use of calcium channel blockers (dihydropyridine)

- Use of ACE inhibitors

- Use of angiotensin receptor antagonists

10 000+ happy customers
100% satisfaction
★ ★ ★ ★ ★ customer support

Understand blood, stool, and urine medical results from all your laboratories.

Upload Your Personal Results

Upload Personal Results

For professional account plans go here

for professional account plans go here

Monthly plan

Annual plan

Own it for life

  • Subscription
  • Data entry service included

    Data entry service

    Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.

  • Instant interpretation
  • Use free data entry form

    Free data entry form

    We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.

  • 4000+ biomarkers explained
  • Nutrition recommendations
  • Cancel anytime


$15 /month

billed every month

  • monthly
  • $15 per report
  • ✓ Instant interpretations
  • ✓ 4000+ biomarkers explained
  • ✓ Nutrition recommendations
  • ✓ Free data entry form
  • ✓ Unlimited data
  • ✓ $15 data entry service
  • ✓ Cancel anytime

Most popular

Data entry included


$79 /year

$6.60/month billed annually

  • yearly
  • 5 reports free
  • ✓ Instant interpretations
  • ✓ 4000+ biomarkers explained
  • ✓ Nutrition recommendations
  • ✓ We enter 5 reports for you
  • ✓ Yearly subscription
  • ✓ Cancel anytime

Data entry included


$250 /once

own it for life

  • pay once
  • 10 reports free
  • ✓ Instant interpretations
  • ✓ 4000+ biomarkers explained
  • ✓ Nutrition recommendations
  • ✓ We enter 10 reports for you
  • ✓ No subscription
  • ✓ Dedicated support
  • ✓ Unlimited access

Are You a Health Professional?

Get started with our professional plan

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more

Pro Monthly Plus

for health professionals

  • ✓ Track multiple clients results
  • ✓ No setup fees
  • ✓ No hidden costs
  • ✓ Instant interpretations
  • ✓ 4000+ biomarkers explained
  • ✓ Includes data entry service
  • ✓ Personal training and support
  • ✓ Cancel anytime

$75 per month

Use promo code to save 10% off any plan.

We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.