Estradiol
Other names: Oestradiol, Estradiol, Serum, MS, ESTRADIOL, LC/MS, ESTRADIOL (E2)
Estradiol (Estrogen) is a female hormone, produced primarily in the ovary. The amount of estrogen produced depends on the phase of the menstrual cycle.
Men also produce estradiol, but only very small amounts.
Shortly before ovulation, estradiol levels surge and then fall immediately after ovulation. They then rise again and remain elevated until 2-3 days before menstruation.
- If pregnancy occurs, the estradiol levels remain elevated.
- If pregnancy does not occur, then estradiol levels fall, which, in combination with falling progesterone levels, provoke a menstrual flow.
Normal Values:
| Men | 13-42 pg/ml | 48-154 pmol/L |
|
Women |
60-250 pg/ml | 220-918 pmol/L |
| Women (Luteal Phase) |
75-450 pg/ml | 275-1650pmol/L |
| Women (Menopausal) |
<10 pg/ml | <40 pmol/L |
| Women (Menopausal on estrogen replacement) |
50-100 pg/ml | 184-367 pmol/L |
What does it mean if your Estradiol result is too high?
Elevated estradiol levels in women can indicate various health issues and require thorough evaluation for accurate diagnosis. Estradiol is a crucial form of estrogen responsible for the development and regulation of the female reproductive system and secondary sexual characteristics. High estradiol levels can be associated with conditions like polycystic ovary syndrome (PCOS), ovarian tumors, and endometriosis. Possible causes of elevated estradiol include hormone replacement therapy, certain medications, excessive body fat, and endocrine disorders. Symptoms of high estradiol may include irregular menstrual cycles, weight gain, mood swings, and an increased risk of blood clots. Diagnosis typically involves blood tests to measure hormone levels and may include imaging studies and a detailed medical history review.
Treatment options vary depending on the underlying cause. For instance, if PCOS is the culprit, treatments might include lifestyle changes like weight loss, medications such as birth control pills to regulate menstrual cycles, or anti-androgens to alleviate symptoms. If ovarian tumors are responsible, surgical intervention may be necessary. Adjustments or discontinuation of hormone therapy might be required if medications are causing the elevation. Other biomarkers that are often correlated with high estradiol levels include luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone, which can provide additional insights into hormonal balance and aid in diagnosis. Monitoring these levels helps guide treatment and ensure overall hormonal health. Managing elevated estradiol levels involves a comprehensive approach that addresses both symptoms and root causes to restore hormonal balance and improve overall health.
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What does it mean if your Estradiol result is too low?
Decreases found in:
- Menopause
- Pituitary failure
- Adrenal failure
- Ovarian failure
- Luteal Phase Deficiency
Normal Values:
| Men | 13-42 pg/ml | 48-154 pmol/L |
|
Women |
60-250 pg/ml | 220-918 pmol/L |
| Women (Luteal Phase) |
75-450 pg/ml | 275-1650pmol/L |
| Women (Menopausal) |
<10 pg/ml | <40 pmol/L |
| Women (Menopausal on estrogen replacement) |
50-100 pg/ml | 184-367 pmol/L |
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