DHEA - Saliva

Saliva
check icon Optimal Result: 42 - 578 pg/mL.

DHEA - Saliva (pg/mL): An Overview

DHEA (Dehydroepiandrosterone) is a steroid hormone produced primarily by the adrenal glands, with smaller contributions from the ovaries or testes. It serves as a precursor for other sex hormones, such as testosterone and estrogen, and plays a critical role in regulating various physiological processes. Measuring DHEA levels in saliva provides insight into adrenal gland function, hormonal balance, and overall health.


Why Measure DHEA in Saliva?

Saliva testing offers a non-invasive, convenient method to assess bioavailable DHEA. Unlike serum testing, which measures both bound and unbound hormone levels, saliva testing reflects the active, free form of DHEA that is readily available for use by the body.


Normal Ranges

DHEA levels vary based on age, sex, and time of day. They are typically highest in the morning and decline throughout the day. The reference range for DHEA in saliva is generally expressed in pg/mL and may vary slightly between laboratories.


Functions of DHEA

  1. Hormone Production: Acts as a precursor for testosterone and estrogen synthesis.
  2. Stress Response: Helps modulate the body's reaction to stress by balancing cortisol levels.
  3. Immune System Support: Enhances immune function and reduces inflammation.
  4. Bone Health: Supports bone density by interacting with other hormones like estrogen.
  5. Cognitive Health: Plays a role in memory, mood, and overall brain function.

What Do Abnormal Levels Indicate?

High DHEA Levels

Elevated levels of DHEA in saliva may indicate:

  • Adrenal Hyperactivity:
    • Often linked to chronic stress or overactivation of the hypothalamic-pituitary-adrenal (HPA) axis.
  • Polycystic Ovary Syndrome (PCOS):
    • Common in women, with symptoms like irregular periods, hirsutism, and acne.
  • Androgen Excess:
    • Can lead to symptoms like increased body hair, oily skin, or hair loss.
  • Adrenal Tumors or Disorders:
    • Rare but may contribute to increased DHEA production.

Low DHEA Levels

Reduced DHEA levels may suggest:

  • Adrenal Insufficiency or Fatigue:
    • Often caused by chronic stress, leading to depleted adrenal reserves.
  • Aging:
    • DHEA production naturally declines with age, typically starting in the mid-30s.
  • Chronic Illness or Immune Dysfunction:
    • Conditions like autoimmune diseases or prolonged infections may lower DHEA levels.
  • Hormonal Imbalances:
    • Low DHEA can disrupt estrogen and testosterone synthesis, leading to fatigue, low libido, and mood changes.

Clinical Uses of DHEA Testing

  • Stress and HPA Axis Assessment:
    • Evaluates the balance between DHEA and cortisol to identify stress-related imbalances.
  • Hormonal Health Monitoring:
    • Helps diagnose conditions like PCOS, adrenal fatigue, or menopause-related symptoms.
  • Anti-Aging Research:
    • Used to track hormone decline and its impact on physical and cognitive health.
  • Athletic Performance:
    • Assesses hormonal balance in athletes to prevent overtraining or stress-induced imbalances.

How to Optimize DHEA Levels

  1. Manage Stress:
    • Practice relaxation techniques like mindfulness, yoga, or meditation to support adrenal health.
  2. Improve Sleep Hygiene:
    • Aim for 7–9 hours of quality sleep to maintain healthy hormone cycles.
  3. Balanced Diet:
    • Include nutrient-dense foods rich in zinc, magnesium, and healthy fats to support hormone production.
  4. Exercise Moderately:
    • Regular, moderate physical activity can improve hormonal balance without overtaxing the adrenal glands.
  5. Consider Supplementation:
    • In cases of low DHEA, healthcare providers may recommend DHEA supplements under supervision.

Conclusion

The DHEA - Saliva (pg/mL) test is a valuable tool for assessing adrenal health, hormonal balance, and overall well-being. Abnormal levels can provide critical insights into stress response, aging, and endocrine function. By addressing underlying causes and adopting a proactive approach, individuals can optimize their DHEA levels and enhance their overall health. Always consult a healthcare provider for personalized interpretation and guidance.

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