Cortisol-Binding Globulin (CBG)


A healthy result should fall into the range 19 - 45 mg/L, or 1.90 - 4.50 mg/dL.

Cortisol-binding globulin (CBG) is a serum alpha-2-globulin-binding protein with high affinity and limited capacity for cortisol. It binds most (±92%) of the serum cortisol; the remaining cortisol (±8%) circulates in a free form or bound to albumin.

Cortisol-binding globulin (CBG) is synthesized in the liver.

The Cortisol-binding globulin (CBG) assay is helpful in assessing unexpected values of blood cortisol. Other assays useful in diagnosis and therapy of cortisol abnormalities include plasma cortisol, ACTH, β-lipotropin, urinary cortisol (by HPLC), or free cortisol in plasma or serum.

Cortisol-Binding Globulin (CBG) result calculator

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