Insulin-like growth factor-binding protein 1 is a member of the family of structurally homologous proteins (= those with a common evolutionary origin) that specifically binds and modulates the activities of IGF-1 and IGF-2.
Serum levels of IGFBP-1 exhibit considerable diurnal variation (= the variations occur in response to circadian rhythms) with levels highest early in the morning and lowest in the evening. Serum IGFBP-1 levels are controlled by insulin with the postprandial increase (= after a meal) in insulin levels producing a four- to fivefold decrease in IGFBP-1 levels relative to fasting levels.
Ranke MB, Elmlinger M. Functional role of insulin-like growth factor binding proteins. Horm Res. 1997; 48(Suppl 4):9-15 (review). PubMed 9350439
Lee PD, Conover CA, Powell DR. Regulation and function of insulin-like growth factor-binding protein-1. Proc Soc Exp Biol Med. 1993 Oct; 204(1):4-29. PubMed 7690486
Hills FA, Gunn LK, Hardiman P, Thamaratnam S, Chard T. IGFBP-1 in the placenta, membranes and fetal circulation: Levels at term and preterm delivery. Early Hum Dev. 1996 Jan 5; 44(1):71-76. PubMed 8821897
Hills FA, English J, Chard T. Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: Relation to birthweight and maternal weight. J Endocrinol. 1996 Feb; 148(2):303-309. PubMed 8699144
Grobman WA, Kazer RR. Serum insulin, insulin-like growth factor-I, and insulin-like growth factor binding protein-1 in women who develop pre-eclampsia. Obstet Gynecol. 2001 Apr; 97(4):521-526. PubMed 11275021
→ Type 2 diabetics tend to have low serum IGFBP-1 levels.
→ Low levels are observed in acromegaly, Cushing disease, and polycystic ovary syndrome.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
→ IGFBP-1 levels have been shown to be elevated in type 1 diabetics and in patients with insulin resistance syndromes.
→ Patients with growth hormone deficiency tend to have elevated IGFBP-1 levels.
IGFBP-1 is the predominant IGF-binding protein in amniotic fluid and in fetal and maternal circulation. The levels are high in the fetus and newborn, but decline steadily until puberty. In a recent study of women in the second trimester of pregnancy, IGFBP-1 levels were higher in women who subsequently developed preëclampsia than in matched controls who did not develop the syndrome.
Interpret Your Lab Results
Upload your lab report and we’ll interpret and provide you with recomendations today.Get Started
Get Started With Our Personal Plan
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
for health professionals
$45 per month
17-OH Progesterone, ACTH, Plasma, ADH, Aldos/Renin Ratio, Aldosterone, Anti-Mullerian Hormone (AMH), Cortisol - AM (Serum), Cortisol, Serum, Cortisol-Binding Globulin (CBG), DHEAS (Serum), Estradiol, Estradiol (male), Estradiol, Ultrasensitive, LC/MS, Estrogens, Total (female), Estrogens, Total (male), Estrone, Serum (Female), Estrone, Serum (Male), Free Cortisol, Serum, Glucagon, Growth Hormone, Human Chorionic Gonadotropin (hCG), Total, IA-2 Autoantibodies, IGF Binding Protein 1 (IGFBP 1), Leptin, Progesterone (male), Progesterone (Serum), Prolactin, Renin Activity, Plasma