Insulin-like growth factor-binding protein 1 is a member of the family of structurally homologous proteins (= those with a common evolutionary origin) that specifically binds and modulates the activities of IGF-1 and IGF-2.
Serum levels of IGFBP-1 exhibit considerable diurnal variation (= the variations occur in response to circadian rhythms) with levels highest early in the morning and lowest in the evening. Serum IGFBP-1 levels are controlled by insulin with the postprandial increase (= after a meal) in insulin levels producing a four- to fivefold decrease in IGFBP-1 levels relative to fasting levels.
References:
Ranke MB, Elmlinger M. Functional role of insulin-like growth factor binding proteins. Horm Res. 1997; 48(Suppl 4):9-15 (review). PubMed 9350439
Lee PD, Conover CA, Powell DR. Regulation and function of insulin-like growth factor-binding protein-1. Proc Soc Exp Biol Med. 1993 Oct; 204(1):4-29. PubMed 7690486
Hills FA, Gunn LK, Hardiman P, Thamaratnam S, Chard T. IGFBP-1 in the placenta, membranes and fetal circulation: Levels at term and preterm delivery. Early Hum Dev. 1996 Jan 5; 44(1):71-76. PubMed 8821897
Hills FA, English J, Chard T. Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: Relation to birthweight and maternal weight. J Endocrinol. 1996 Feb; 148(2):303-309. PubMed 8699144
Grobman WA, Kazer RR. Serum insulin, insulin-like growth factor-I, and insulin-like growth factor binding protein-1 in women who develop pre-eclampsia. Obstet Gynecol. 2001 Apr; 97(4):521-526. PubMed 11275021
→ Type 2 diabetics tend to have low serum IGFBP-1 levels.
→ Low levels are observed in acromegaly, Cushing disease, and polycystic ovary syndrome.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get your interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
→ IGFBP-1 levels have been shown to be elevated in type 1 diabetics and in patients with insulin resistance syndromes.
→ Patients with growth hormone deficiency tend to have elevated IGFBP-1 levels.
IGFBP-1 is the predominant IGF-binding protein in amniotic fluid and in fetal and maternal circulation. The levels are high in the fetus and newborn, but decline steadily until puberty. In a recent study of women in the second trimester of pregnancy, IGFBP-1 levels were higher in women who subsequently developed preëclampsia than in matched controls who did not develop the syndrome.
Interpret Your Lab Results
Upload your lab report, and we'll interpret and provide you with recommendations today.
Get Started
Monthly plan
Annual plan
Own it for life
Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
$15 /month
billed every month
Most popular
Data entry included
$79 /year
$6.60/month billed annually
Data entry included
$250 /once
own it for life
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Monthly Plus
for health professionals
$75 per month
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
17-Hydroxypregnenolone, MS (female), 17-OH Progesterone, ACTH, Plasma, ADH, Aldos/Renin Ratio, Aldosterone, Aldosterone/Plasma Renin Activity Ratio, Anti-Mullerian Hormone (AMH), Calcitonin, Serum, Cortisol - ACTH (Cortrosyn) Stimulation Test, Cortisol - AM (Serum), Cortisol, Serum, Cortisol-Binding Globulin (CBG), DHEA-S : Cortisol Ratio, DHEAS (Serum), Estradiol, Estradiol (male), Estradiol, Ultrasensitive, LC/MS, Estriol, Serum, Estrogens, Total (female), Estrogens, Total (male), Estrone, Serum (Female), Estrone, Serum (Male), Free Cortisol, Serum, Glucagon, Growth Hormone, Human Chorionic Gonadotropin (hCG), Total, IA-2 Autoantibodies, IGF Binding Protein 1 (IGFBP 1), Leptin, Progesterone (male), Progesterone (Serum), Prolactin, Renin Activity, Plasma
