Estradiol, a form of estrogen, is a critical hormone in the human body, primarily responsible for regulating reproductive and sexual health. The Estradiol - Saliva test measures the level of estradiol present in saliva, expressed in picograms per milliliter (pg/mL). Unlike serum tests, saliva testing reflects the bioavailable (free) fraction of estradiol, which is the active form readily used by the body.
Reproductive Health:
Bone Health:
Cardiovascular Health:
Skin and Hair:
Cognitive and Emotional Well-Being:
Saliva testing is non-invasive, convenient, and measures the active hormone levels, providing a more accurate picture of hormonal activity in tissues compared to total hormone levels in the blood. This makes it particularly useful for:
Optimal ranges vary depending on age, sex, and reproductive status. For adult women:
For men, typical ranges are generally lower, around <0.5 pg/mL.
Hormone Replacement Therapy (HRT):
Reproductive Health:
Perimenopause and Menopause:
Chronic Conditions:
While estradiol is primarily known as a female hormone, it plays an essential role in men’s health as well. In men, estradiol is produced in small amounts through the conversion of testosterone by the enzyme aromatase. The Estradiol - Saliva test provides insights into bioavailable estradiol levels, which influence various physiological processes in men. Estradiol is critical for maintaining bone density, cardiovascular health, cognitive function, and libido. However, when estradiol levels are imbalanced—either too high or too low—it can lead to significant health concerns. Elevated estradiol levels in men are often associated with obesity, as excess adipose tissue increases aromatase activity, leading to higher estrogen conversion. This condition, commonly referred to as estrogen dominance, can result in symptoms such as gynecomastia (breast tissue enlargement), reduced libido, emotional changes, and decreased energy. Low estradiol levels, on the other hand, may occur with low testosterone states, certain medications, or endocrine dysfunction, and can lead to symptoms like osteoporosis, joint pain, reduced muscle mass, and decreased sexual function. In men, estradiol balance is critical for ensuring optimal testosterone function, as imbalances can inhibit testosterone’s effectiveness or disrupt the hypothalamic-pituitary-gonadal (HPG) axis. The saliva test is particularly useful for monitoring men undergoing testosterone replacement therapy (TRT), as increased testosterone levels can sometimes elevate estradiol levels through aromatization, requiring additional interventions to maintain balance. Addressing out-of-range estradiol levels in men typically involves lifestyle adjustments, weight management, dietary changes, or medical treatments such as aromatase inhibitors.
The Estradiol - Saliva (pg/mL) test provides valuable insights into active hormone levels, helping assess estrogen’s role in reproductive health, aging, and overall well-being. Interpreting estradiol levels in the context of symptoms and lifestyle factors is essential for guiding interventions that optimize hormonal balance and improve quality of life. Always consult a healthcare provider for personalized recommendations based on test results.
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Elevated estradiol levels in women can indicate estrogen dominance, a condition where estrogen levels are disproportionately high relative to other hormones like progesterone. This imbalance can be caused by hormone replacement therapy (HRT), polycystic ovary syndrome (PCOS), chronic stress, or exposure to environmental estrogens (xenoestrogens) found in plastics and pesticides. Other potential causes include obesity, where fat cells contribute to excess estrogen production, or conditions like endometriosis, uterine fibroids, or hormone-producing tumors. Symptoms of elevated estradiol may include irregular or heavy menstrual cycles, breast tenderness, weight gain, mood swings, and an increased risk of conditions like endometrial hyperplasia or breast cancer over time. Managing elevated estradiol often involves addressing the underlying cause, balancing hormones through dietary changes, stress reduction, or targeted medical therapies such as progesterone supplementation or estrogen blockers.
In men, elevated estradiol levels can occur due to increased aromatase activity, which converts testosterone into estrogen. This is often associated with obesity, as adipose tissue is a significant site of aromatase expression, or as a side effect of testosterone replacement therapy (TRT), where excess testosterone can be converted to estradiol. Elevated estradiol in men may result in estrogen dominance, leading to symptoms like gynecomastia (breast tissue enlargement), reduced libido, mood changes, fatigue, and even erectile dysfunction. Chronic elevated estradiol levels may interfere with testosterone’s action, disrupting the hormonal balance and the hypothalamic-pituitary-gonadal (HPG) axis. This can impact overall vitality, muscle mass, and bone density. Treatment typically involves lifestyle changes, such as weight loss, dietary adjustments to reduce aromatase activity, or medical interventions like aromatase inhibitors to lower estradiol levels and restore hormonal balance.
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I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
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What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
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As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
Healthmatters is a highly-personalized health dashboard.
Instead of searching for your lab results in different places or tracking them down from different providers, Healthmatters houses, organizes, and interprets them all in one central location.
With a Healthmatters account, you can dive into the details of each biomarker and gain insights into the meaning behind your medical test data, anytime, anywhere.
For our professional users, Healthmatters provides intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history.
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you’re on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our special data entry service makes it easy to add your results to your private dashboard. Just attach an image or a file of your lab test results, and our skilled data entry team will do the work for you. It's all done by humans, ensuring that your data is entered accurately and with personal care for each client.
Depending on your account, the data entry service can be included for free or come at an additional cost of $15 per report.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
The Unlimited plan is a one-time purchase for $250, and it covers your account for a lifetime with no additional payments.
For the Complete plan, the cost is $15 per month. You have the flexibility to cancel it anytime through your account settings, ensuring no further payments. To avoid charges, remember to cancel at least a day before the renewal date. Once canceled, the subscription remains active until the end of the current billing cycle.
Additionally, you can upgrade to the yearly Advanced plan from within your account. The annual cost is $79, and it comes with a data entry service for five reports.
You can always upgrade to a lifetime version with a prorated price from a monthly or yearly subscription.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We’ve crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewExplore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
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17-Hydroxypregnenolone, MS (female), 17-Hydroxyprogesterone (female), 17-OH Progesterone, 5 Alhpa-Dihydrotestosterone (male), ACTH, Plasma, ADH, Aldos/Renin Ratio, Aldosterone, Aldosterone/Plasma Renin Activity Ratio, Anti-Mullerian Hormone (AMH), C-Telopeptide, Serum, Calcitonin, Serum, Cortisol - ACTH (Cortrosyn) Stimulation Test, Cortisol - AM (Serum), Cortisol – saliva, Cortisol, Serum, Cortisol-Binding Globulin (CBG), Dexamethasone, DHEA - Saliva, DHEA, Unconjugated, DHEA-S : Cortisol Ratio, DHEAS (Serum), DHT, Free, DHT, Percent Free Dialysis, Estradiol, Estradiol (male), Estradiol - Saliva, Estradiol, Ultrasensitive, LC/MS, Estriol, Serum, Estrogens, Total (female), Estrogens, Total (male), Estrone Sulfate, Estrone, Serum (Female), Estrone, Serum (Male), Free Cortisol, Serum, Free Estradiol, Percent, Free Estradiol, Serum, Free Testosterone - Saliva, Glucagon, Gonadotropin Releasing Hormone (GnRH), Growth Hormone, Human Chorionic Gonadotropin (hCG), Total, IA-2 Autoantibodies, IGF Binding Protein 1 (IGFBP 1), IGF Binding Protein 3 (IGFBP 3), IGF-BP3, Leptin, Luteinizing Hormone, Human (hLH), Pregnenolone (male), Progesterone (male), Progesterone (Serum), Prolactin, Renin Activity, Plasma, Total Testosterone (Female/ng/mL)
