A healthy result should fall into the range 50 - 170 pg/mL.
Total estrogen is a lab test done to measure the overall estrogen status. It’s one of the reliable tests you could do for estrogen status and will detect hormone imbalances. It does not categorize the levels of estradiol (E2) and estrone (E1), but instead gives only the total amount of estrogen found in the blood.
Estrogens don’t only come from the ovaries. The adrenal glands and placenta also secrete them. Men have low levels of estrogen produced in their bodies as well as testosterone.
Normal Ranges for Total Estrogen in pg/mL:
Adult Female (depends on the menstrual phase)
Follicular Phase (1-12 days) 90-590 pg/mL
Luteal Phase 130-460 pg/mL
Postmenopausal 50-170 pg/mL
Adult Male 60-190 pg/mL
Critical Range: anything outside the limits mentioned above.
Low levels of total estrogen may result in symptoms in women such as
- Lack of menstrual period
- Lack of sex organ development
Some specific reasons why total estrogens might be low include:
- Eating disorders, especially anorexia
- Polycystic Ovarian Syndrome
- Strenuous and continuous exercise regimens
- Ovarian dysfunction
- Low levels of pituitary hormone
- Turner Syndrome, a genetic condition
High levels of total estrogen may result in symptoms in men such as enlarged breasts, called gynecomastia. In boys, it can cause delayed puberty.
In women, high levels of estrogen may cause breakthrough bleeding, interfere with pregnancy attempts, or cause unusual sex organ development.
Some specific causes of high total estrogens might be:
- Exposure to estrogenic compounds in the environment
- Medication overdose such as with hormone replacement or birth control pills
- Early puberty
- Ovarian tumors
- Tumor of the adrenal glands
- Testicular tumors
- Cirrhosis of the liver
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