Estriol, Serum

Optimal Result: 0 - 0.21 ng/mL.

Estriol is one of three estrogen hormones. Estriol levels rise throughout pregnancy, helping to keep your uterus and unborn baby healthy. The levels are at their highest right before childbirth. They help prepare your body for labor and delivery.

Everyone makes estriol. But in people who aren’t pregnant, the levels are almost undetectable. Other names for estriol include oestriol and E3.

During pregnancy, estriol:

- Helps your uterus grow as the fetus gets bigger.
- Makes your body more sensitive to other pregnancy hormones.
- Prepares your body for labor and delivery and breastfeeding.

The third estrogen is known as Estriol (E3) and is produced in significant amounts during pregnancy. In men and women, Estriol is irreversibly produced by estradiol (estriol cannot make estradiol) or from estrone through 16-OH-Estrone which makes it the largest circulating estrogen because both Estrone and Estradiol can make it. Despite this, estriol is not nearly as potent as estradiol (Estradiol is 80x more potent!). The least potent of the estrogens, Estriol (E3) levels are traditionally used clinically to gauge the viability of pregnancies. In the context of this profile, estriol is least likely to be associated with high-estrogen problems (e.g. breast cancer), and is generally viewed as a "protective" estrogen. Conversion of 16alpha-hydroxyestrone to estriol is important to consider.

Note: If one is taking a "Bi-Est" or "Tri-Est" preparation, an elevated estriol is not unusual.

Reference Ranges:

Adult Male ≤0.18 ng/mL
Adult Female (Non-pregnant) ≤0.21 ng/mL
Pregnancy  
First trimester ≤2.50 ng/mL
Second trimester ≤9.60 ng/mL
Third trimester ≤14.60 ng/mL

References:

https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/81711

What does it mean if your Estriol, Serum result is too low?

Doctors usually test E3 during pregnancy, when it temporarily becomes the main estrogen. Abnormal levels of estriol may be a sign of problems with the baby’s health -- but you’d get a lot more tests to find out for sure. You might need several tests to track changes in your estrogen levels over time.

What does it mean if your Estriol, Serum result is too high?

High estriol implies a potential for elevated 16alpha-hydroxyestrone (16-OH-E1), a very potent estrogen that is associated with increased risk of breast cancer. There appears to be an association of elevated estriol and elevated 16alpha-hydroxyestrone in patients with systemic lupus erythematosus, implying shifted metabolism in that condition.

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