Kynurenic acid, which is derived from the processing of tryptophan, is converted to quinolinic acid in the presence of B6 or P5P. While kynurenic is calming, quinolinic is an excitotoxin that can over stimulate nerves.
A high ratio indicates excessive inflammation due to recurrent infections, excessive tryptophan intake, immune overstimulation, excessive adrenal production of cortisol, or excessive exposure to phthalates.
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