Metabolic Analysis Markers (Urine)

Dihydroxyphenylpropionic Acid (DHPPA)

Optimal Result: 0 - 5.3 mmol/mol creatinine.

Alternative names:

Dihydroxyphenylpropionate

What is 3,4 Dihydroxyphenylpropionate?

3,4-Dihydroxyphenylpropionate seems to be strongly associated with a troublesome type of bacteria called Clostridia.

What is Clostridia?

This organism is frequently the cause of travelers diarrhea, but its by-products may produce other symptoms.

Clostridium species constitute a major portion of the bacteria of the lower ileum and colon. Being strictly anaerobic, they are difficult to culture from stool and are not reported on most stool cultures.

Cases of confirmed Clostridium overgrowth show elevated levels of Dihydroxyphenylpropionate, which fall to baseline with Flagyl treatment, but are unaffected by nystatin.

Further info on Dihydroxyphenylpropionate:

In health, beneficial intestinal bacteria produce some B-vitamins and provide stimulus for proper immune function. However, if your stomach acid is not adequate, if you fail to digest protein, or if your diet does not supply sufficient fiber, the resulting overgrowth of unfavorable bacteria can release toxic products that your body must remove. These toxic products include Dihydroxyphenylpropionate.

References:

  • https://www.ncbi.nlm.nih.gov/pubmed/19152477
  • Laboratory Evaluations for Integrative and Functional Medicine, edited by Richard S. Lord, J. Alexander Bralley

What does it mean if your Dihydroxyphenylpropionic Acid (DHPPA) result is too high?

DHPPA in urine indicates intake of chlorogenic acid, a common substance in beverages and many fruits and vegetables. Harmless or beneficial bacteria such as Lactobacilli, Bifidobacteria, and E. coli increase the breakdown of chlorogenic acid to DHPPA so high values are mainly associated with increased amounts of these species in the GI tract.

Possible causes:

- Clostridium overgrowth and/ or malabsorption of tryptophan, tyrosine and/or phenlyalanine

Additional investigations:

- Investigate possible causes of malabsorption

- Intestinal Permeability

- IgG Food Sensitivity

- Complete Digestive Stool Analysis

Treatment considerations:

- Antimicrobials

- Probiotics

- Mucosal support

- Betaine HCl

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