If you can test it, we can track it — all test results, including the ones from your favorite labs.

Optimal Result: 0.33 - 1.01 mmol/mol creatinine.

Orotic Acid is a sensitive marker of your liver’s capacity to convert toxic ammonia to non-toxic urea that you can excrete. That capacity can be increased by additional arginine. Ammonia toxicity can also be reduced by supplementation with α-ketoglutarate, magnesium, aspartic acid, and glutamic acid. Ammonia impairs brain function, causing difficulty with thinking, fatigue, headaches, and increased food sensitivities. Associated nutrients: Arginine, Magnesium

References:

https://www.ncbi.nlm.nih.gov/pubmed/27906623

What does it mean if your Orotic Acid result is too low?

- Low orotic acid in the presence of high ammonia indicates magnesium deficiency.

- Low orotic acid together with low urea levels suggests your cells are not burning protein for fuel at a very high rate. This is consistent with elevated branched-chain amino acids (leucine, isoleucine and valine). It also means that you do not have gut bacteria that are producing a lot of ammonia. Check the bacterial dysbiosis markers to see if they’re consistent.

What does it mean if your Orotic Acid result is too high?

Elevations are most commonly associated with ammonia toxicity. Elevated ammonia may result from drug toxicity to the liver, viral liver infection, gastrointestinal bleeding, or inborn errors of ammonia metabolism. Confirmation of a genetic disorder requires testing plasma amino acids.

Possible causes:

- liver damage (e.g. from alcohol)

- urea cycle dysfunction

- ammonia excess

- barbiturates

- impaired metabolism due to cofactor insufficiencies (vitamins B3, B6, folate, Mg, glutamine, glycine, serine)

- use of allopurinol or chemotherapy

Additional investigations:

- Functional Liver Detoxification Profile

- Vitamins & Minerals Analysis

- Urinary Amino Acids

Possible treatments:

- Supplement vitamins B3, B6, folic acid, Mg, glutamine, glycine, serine

- Consider alpha-ketoglutarate and arginine for ammonia excess

- Support liver

- Antioxidants

If you can test it, we can track it — all test results, including the ones from your favorite labs.

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Essential Plan


  • Monthly subscription
  • Instant interpretation
  • Use the free self-upload form
  • Additional charge for upload service
  • 1500+ biomarkers explained
  • Recommendations
  • Cancel anytime

Advanced Plan


  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 1500+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium plan


  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 1500+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals