If you can test it, we can track it — all test results, including the ones from your favorite labs.

Optimal Result: 1.2 - 5.3 mmol/mol creatinine.

Homovanillate (aka Homovanillic Acid) is a dopamine metabolite.

Homovanillate and Vanilmandelate are breakdown products from neurotransmitters involved in hormone and nerve impulse transmission, called catecholamines.

What does it mean if your Homovanillic Acid result is too low?

When these compounds are low, it indicates your body is not making enough of these neurotransmitters. Low Homovanillate indicates low levels of dopamine. Symptoms associated with this condition are depression, sleep disturbances, inability to deal with stress, and fatigue.

Possible causes:

- Low precursors/neurotransmitters (phenylalanine, dopamine, noradrenalin)

- Low cofactors (B2, B3, B6, Mg or Fe)

- Impaired methylation

Additional investigations:

- Vitamins & Minerals Analysis

Treatment considerations:

Treatments to improve digestion, along with supplementation of tyrosine or phenylalanine, can help improve the ability to keep up with demand for these neurotransmitters.

- L-tyrosine & B6

- B2, B3 or Fe if low

- Support methylation (methionine/SAMe, B6, B12, folate, Mg)

What does it mean if your Homovanillic Acid result is too high?

Elevations of Homovanillate and Vanilmandelate indicate an over-activation of nervous system function involving these neurotransmitters. This can be for various reasons, but is most commonly associated with stress, both internal (e.g., mental/emotional) and external (e.g., environmental toxins). Addressing the source of stress and improving the body’s ability to handle stress are useful in these cases.

Possible causes:

- Increased catecholamine activity/stress pattern

- Impaired production of noradrenalin from dopamine

Additional investigations:

- Adrenal Hormone Profile

Treatment considerations:

- Adrenal support

- Stress management

If you can test it, we can track it — all test results, including the ones from your favorite labs.

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