Homogentisic Acid

Optimal Result: 0 - 19 mmol/mol creatinine.

Homogentisic acid, also known as melanic acid, is an intermediate in the breakdown or catabolism of tyrosine and phenylalanine.



What does it mean if your Homogentisic Acid result is too high?

Possible causes:

- Impaired metabolism due to cofactor insufficiency (iron, vitamin C, 02)

- Chronically high levels of homogentisic acid are associated with alkaptonuria, an inborn error of metabolism. Alkaptonuria is a rare inherited genetic disorder in which the body cannot process the amino acids phenylalanine and tyrosine.

Additional investigations:

- Iron studies

Treatment considerations:

- Supplement iron if low

- Vitamin C

- Improve oxygenation

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