Homogentisic acid, also known as melanic acid, is an intermediate in the breakdown or catabolism of tyrosine and phenylalanine.
- Impaired metabolism due to cofactor insufficiency (iron, vitamin C, 02)
- Chronically high levels of homogentisic acid are associated with alkaptonuria, an inborn error of metabolism. Alkaptonuria is a rare inherited genetic disorder in which the body cannot process the amino acids phenylalanine and tyrosine.
- Iron studies
- Supplement iron if low
- Vitamin C
- Improve oxygenation
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