Metabolic Analysis Markers (Urine)

Formiminoglutamic Acid (FIGlu)

Optimal Result: 0 - 1.5 mmol/mol creatinine.

Formiminoglutamic Acid (FIGlu) is a functional marker of insufficiency of folic acid, another B-vitamin, and is a compound made from the amino acid histidine.

Pregnant women especially need to have adequate folic acid to prevent birth defects. Folic acid insufficiency can play a role in childhood development problems, depression, immune function, and is a risk factor for cardiovascular disease.

Insufficiency of folic acid leads to high urinary Formiminoglutamic Acid.

What does it mean if your Formiminoglutamic Acid (FIGlu) result is too high?

High levels can indicate:

- insufficient folic acid

- increased alcohol consumption

- excessive consumption of processed foods

- oral contraception

Smoking and pregnancy will all have a detrimental impact on folic acid absorption.

Symptoms:

Common symptoms may include:

- anemia

- fatigue

- elevated homocysteine

- ischemic heart disease

- stroke

- deep vein thrombosis.

Pregnant women especially need to have adequate folic acid to prevent birth defects.

Folic acid insufficiency can play a role in:

- childhood development problems

- depression

- immune function

Folic acid insufficiency is a risk factor for cardiovascular disease.

Possible treatment options if high:

- consider supplementing with folic acid.

- stop consumption of alcohol.

- if homocysteine is elevated, consider using 5-methyltetrahydrofolate.

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