Metabolic Analysis Markers (Urine)

Beta-OH-Butyric Acid (BHBA)

Optimal Result: 0 - 2.8 mmol/mol creatinine.

Other names:

2-Hydroxybutyric Acid

A ketone body produced as by-product of fatty acids oxidation for energy. High levels may occur in certain genetic disorders such as pyruvate dehydrogenase deficiency. Slightly elevated 2- hydroxybutyric acid in urine has little clinical significance.

Elevated 2-hydroxybutyric acid is a byproduct of the breakdown of the sulfur amino acid metabolite, cystathionine, which may be formed in excess during oxidative stress or when toxic exposures increase the need for detoxi cation. When glutathione is depleted by excessive toxic exposure, pyroglutamic acid may also be elevated. May also be elevated due to certain genetic SNPs in the methylation pathway or de ciencies of methyl tetrahydrofolate, methyl B12, or betaine.

What does it mean if your Beta-OH-Butyric Acid (BHBA) result is too high?

High levels may occur in certain genetic disorders such as pyruvate dehydrogenase deficiency. Slightly elevated 2- hydroxybutyric acid in urine has little clinical significance.

The buildup of beta-hydroxy-butyric acid (BHBA) is an indication that fats are not being processed ideally. It is a sign of possible ketosis. Often, higher levels of BHBA are seen in those who have H. pylori, or who do not have sufficient biotin and adenosyl B12 to process fats. Lack of pancreatic enzymes can also be a factor in high BHBA.

Certain diets may cause a greater tendency toward ketosis, such as the Specific Carbohydrate Diet or the Paleolithic Diet. A more balanced diet can be considered if these are factors in ketosis that do not resolve with supplement support.

Possible causes:

Ketosis from carbohydrate unavailability (e.g fasting, diabetes strenuous exercise, ketogenic diet)

10 000+ happy clients
100% satisfaction
★ ★ ★ ★ ★ customer support

Understand blood, stool, and urine medical results from all your laboratories.

Get Started With Our Personal Plan

Advanced Plan

  • ✓ Yearly subscription
  • ✓ Five free uploads
  • ✓ Cancel anytime
  • ✓ Instant interpretations
  • ✓ Use the free self-upload form
  • ✓ 3000+ biomarkers explained
  • ✓ Nutrition Recommendations
  • ✓ Dedicated support
  • ✓ Yearly subscription
  • ✓ Five free uploads
  • ✓ Cancel anytime
$79 per year
  • ✓ Instant interpretations
  • ✓ Use the free self-upload form
  • ✓ 3000+ biomarkers explained
  • ✓ Nutrition Recommendations
  • ✓ Dedicated support

Unlimited Plan

  • ✓ No subscription
  • ✓ Ten free uploads
  • ✓ Unlimited access
  • ✓ Instant interpretations
  • ✓ Use the free self-upload form
  • ✓ 3000+ biomarkers explained
  • ✓ Nutrition Recommendations
  • ✓ Dedicated support
  • ✓ No subscription
  • ✓ Ten free uploads
  • ✓ Unlimited access
$250 full version

Are You a Health Professional?

Get started with our professional plan

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more

Pro Plan

for health professionals

  • ✓ Track multiple clients results
  • ✓ No setup fees
  • ✓ No hidden costs
  • ✓ Cancel anytime
  • ✓ Instant interpretations
  • ✓ Use the free template forms
  • ✓ 3000+ biomarkers explained
  • ✓ Additional team member $25
  • ✓ Personal training and support

$45 per month

Use promo code to save 10% off any plan.


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

×

Understand Your Lab Result Now

  • Instant interpretation
  • 3000+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode: