Roseburia is a genus (=group) of 5 species of bacteria named in the 1980s after American microbiologist Theodor Rosebury. Bacteria in this genus are notable for breaking down sugar, and producing a short-chain fatty acid called butyrate which is important as a food for the cells lining the colon.
The genus Roseburia consists of obligate Gram-positive anaerobic bacteria that are slightly curved, rod-shaped and motile by means of multiple subterminal flagella. It includes five species: Roseburia intestinalis, R. hominis, R. inulinivorans, R. faecis and R. cecicola.
– Gut Roseburia spp. metabolize dietary components that stimulate their proliferation and metabolic activities.
– They are part of commensal bacteria producing short-chain fatty acids, especially butyrate, affecting colonic motility, immunity maintenance and anti-inflammatory properties. Butyrate has been observed to help prevent colorectal cancer and colitis
– Modification in Roseburia spp. representation may affect various metabolic pathways and is associated with several diseases (including irritable bowel syndrome, obesity, Type 2 diabetes, nervous system conditions and allergies).
– Roseburia spp. could also serve as biomarkers for symptomatic pathologies (e.g., gallstone formation) or as probiotics for restoration of beneficial flora.
References:
– A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. [L]
– Roseburia spp.: a marker of health? [L]
– Human Gut Symbiont Roseburia hominis Promotes and Regulates Innate Immunity [L]
– Reduced Dietary Intake of Carbohydrates by Obese Subjects Results in Decreased Concentrations of Butyrate and Butyrate-Producing Bacteria in Feces [L]
– Gut metagenome in European women with normal, impaired and diabetic glucose control. [L]
– Roseburia hominis: a novel guilty player in ulcerative colitis pathogenesis? [L]
A lower abundance of Roseburia has been observed in patients suffering from inflammatory bowel disease. It has also been suggested that a decrease in one particular species, Roseburia hominis, may be associated with ulcerative colitis and irritable bowel syndrome.
– A lower abundance of Roseburia spp. has been associated with Ulcerative Colitis.
– In type 2 diabetes low levels of Lactobacillus and Roseburia can be observed.
– Studies have shown that reduced carbohydrates intake by obese subjects decrease Roseburia spp. and hence butyrate.
– A reduction in a cluster of genes belonging to Roseburia and F. prausnitzii was identified as a discriminant marker for the prediction of diabetic status in European women.
Elevated levels of Roseburia may be associated with weight loss and reduced glucose intolerance.
$79 per year
$6.60 per month billed annually
Use promocode
$79 per year
$250 single payment
$45 per month
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.
Learn More
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
Acetate, Akkermansia muciniphila, Beta defensin 2, Bifidobacterium, Bifidobacterium longum, Butyrate, Butyrivibrio, Calprotectin, Chenodeoxycholic acid (CDCA), Cholic acid (CA), Deoxycholic acid (DCA), Enterobacteriaceae, Eubacterium, Eubacterium rectale, Faecalibacterium prausnitzii, Fecal Anti Gliadin, Fecal Eosinophil Protein X, Fecal lactoferrin, Fecal Occult Blood, Fecal pH, Fecal Zonulin, Lactobacillus, Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, LCA/DCA ratio, Lithocholic acid (LCA), Long chain fatty acids, Lysozyme, Meat Fiber, MMP 9, Pancreatic elastase 1, Propionate, Propionibacterium, Roseburia, S100A12, sIgA, Streptococcus species, Streptococcus thermophilus, Total Cholestrol subfraction, Total Fecal Fat, Total Fecal Triglycerides, Total Phospholipid subfraction, Total Short chain fatty acids, Valerate, Vegetable fiber, ß-glucuronidase
