Optimal Result: 0 - 0.2 ng/mL.

MMP-9 is an important marker of intestinal inflammation. It has been shown to be significantly increased in the stool of UC patients compared with healthy controls and patients with IBS, and was found to correlate with the clinical and endoscopic activity of UC.

MMP-9 as a useful tool in the differential diagnosis of diarrheic disorders and in the noninvasive evaluation of disease activity and mucosal healing in UC. [L]


Annahazi A, Molnar T, Farkas K, Rosztoczy A, Izbeki F, Gecse K, Inczefi O, Nagy F, Foldesi I, Szucs M, Dabek M, Ferrier L, Theodorou V, Bueno L, Wittmann T, Roka R. Fecal MMP-9: a new noninvasive differential diagnostic and activity marker in ulcerative colitis. Inflamm Bowel Dis. 2013 Feb;19(2):316-20. doi: 10.1002/ibd.22996. PMID: 22550024. [L]

What does it mean if your MMP 9 result is too high?

MMP 9 is an inflammatory marker that correlates with the degree of mucosal inflammation in disorders such as Ulcerative Colitis [L].

Consider supplements such as Curcumin, Coumarin, 4-methylesculetin which are anti inflammatory. Calcium supplementation has shown benefit in reducing epithelial permeability and inflammation in the intestine through reduced expression of MMP-9 in some studies.

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