Many studies have reported an increase in the proportion of potentially harmful Proteobacteria, especially of the Enterobacteriaceae family, in IBD patients. Therefore, it would appear that the host’s inflammatory response could be the trigger of gut microbiota imbalance, most likely caused by Enterobacteriaceae blooming, which leads to the persistence of IBD’s inflammatory state.
References:
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Lupp, C.; Robertson, M.L.; Wickham, M.E.; Sekirov, I.; Champion, O.L.; Gaynor, E.C.; Finlay, B.B. Host-Mediated Inflammation Disrupts the Intestinal Microbiota and Promotes the Overgrowth of Enterobacteriaceae. Cell Host Microbe 2007, 2, 204. [L]
Gophna, U.; Sommerfeld, K.; Gophna, S.; Doolittle, W.F.; Veldhuyzen van Zanten, S.J.O. Differences between Tissue-Associated Intestinal Microfloras of Patients with Crohn’s Disease and Ulcerative Colitis. J. Clin. Microbiol. 2006, 44, 4136–4141. [L]
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Carvalho, F.A.; Barnich, N.; Sauvanet, P.; Darcha, C.; Gelot, A.; Darfeuille-Michaud, A. Crohn’s Disease-Associated Escherichia coli LF82 Aggravates Colitis in Injured Mouse Colon via Signaling by Flagellin. Inflamm. Bowel Dis. 2008, 14, 1051–1060. [CrossRef] 18. Mukhopadhya, I.; Hansen, R.; El-Omar, E.M.; Hold, G.L. IBD-What Role Do Proteobacteria Play? Nat. Rev. Gastroenterol. Hepatol. 2012, 9, 219–230. [L]
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Acetate, Akkermansia muciniphila, Beta defensin 2, Bifidobacterium, Bifidobacterium longum, Butyrate, Butyrivibrio, Calprotectin, Chenodeoxycholic acid (CDCA), Cholic acid (CA), Deoxycholic acid (DCA), Enterobacteriaceae, Eubacterium, Eubacterium rectale, Faecalibacterium prausnitzii, Fecal Anti Gliadin, Fecal Eosinophil Protein X, Fecal lactoferrin, Fecal Occult Blood, Fecal pH, Fecal Zonulin, Lactobacillus, Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, LCA/DCA ratio, Lithocholic acid (LCA), Long chain fatty acids, Lysozyme, Meat Fiber, MMP 9, Pancreatic elastase 1, Propionate, Propionibacterium, Roseburia, S100A12, sIgA, Streptococcus species, Streptococcus thermophilus, Total Cholestrol subfraction, Total Fecal Fat, Total Fecal Triglycerides, Total Phospholipid subfraction, Total Short chain fatty acids, Valerate, Vegetable fiber, ß-glucuronidase