Metabolic Health

Glutamic Acid Decarboxylase

A healthy result should fall into the range 0 - 0.5 nmol/L.

Glutamic acid decarboxylase is an enzyme found in brain and pancreas that converts glutamic acid (glutamate) into GABA, an inhibitory neurotransmitter. The glutamic acid decarboxylase test is a test that looks for antibodies directed against the glutamic acid decarboxylase enzyme. While glutamic acid decarboxylase is a critical enzyme in brain, it is also found in beta cells in the pancreas. Some individuals develop autoantibodies against glutamic acid decarboxylase. When these antibodies are detectable in the blood, they may represent an autoimmune disease. The test is performed using radioimmunoassay. The absence or very low levels of glutamic acid decarboxylase autoantibodies are considered normal. Less than 10% of healthy individuals will have low levels of glutamic acid decarboxylase antibodies, suggesting that they may be present in people without disease.

Normal Ranges for Glutamic Acid Decarboxylase:

Less than or equal to 0.02 nmol/L

 

Sources:

https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/81596

https://www.uptodate.com/contents/pathogenesis-of-type-1-diabetes-mellitus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107286/

https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/84221

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