Thyroxine-binding globulin, TBG

Metabolic Health

A healthy result should fall into the range 14 - 31 ug/ml.

Thyroid-binding globulin (TBG) is produced in the liver and is the primary circulating (transport) protein that binds thyroid hormones3,5,3’-triiodothyronine (T3) and thyroxine (T4) and carries them in the bloodstream (think of it like a taxi cab that shuttles T3 and T4 around the body).

There are 2 other thyroid hormone transport proteins (Transthyretin & serum Albumin), but TBG has the highest affinity (=the degree to which a substance tends to combine with another) for T4 and T3 but is present in the lowest concentration.

Reference Ranges:

  • Adult Male: 12.7-25.1 mcg/mL
  • Adult Female 13.5-30.9 mcg/mL

References:

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2417873/
  • https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/thyroxine-binding-globulin

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