Free Androgen Index

Metabolic Health

A healthy result should fall into the range 0 - 6.6 u.

The free androgen index is a measure of the biologically active testosterone in the blood. It is a ratio of the total testosterone to the level of sex hormone-binding globulin (SHBG). About half of all testosterone in the blood is tightly bound to SHBG and the rest is either free or loosely bound to albumin. Only the portion that is free or bound to albumin is considered biologically active. The portion bound to SHBG is considered biologically inert. Thus, by calculating the ratio of total testosterone to SHBG, one can get a measurement of physiologically active testosterone in the blood. The free androgen index is expressed in the same units and multiplied by 100 to provide a number similar to the free testosterone concentration in blood. Normal free androgen index results are slightly higher than free testosterone levels, however. As a ratio, there are no units. The free androgen index may be a more accurate assessment of free testosterone in women than in men.

Normal Ranges for Free Androgen Index:

• Male:

− 20 to 29 years: 30.0−128.0

− 30 to 39 years: 24.0−122.0

− 40 to 49 years: 14.0−126.0

− Older than 49 years: 18.0−82.0

• Female:

− 20 to 49 years: 0.4−8.4

− Older than 49 years: 0.4−6.6

 

Sources:

https://www.labcorp.com/test-menu/25691/free-androgen-index-fai

https://www.labcorp.com/test-menu/35496/testosterone-free-direct

https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=167&ContentID=free_androgen_index

https://www.webmd.com/men/features/low-testosterone-explained-how-do-you-know-when-levels-are-too-low#1

https://www.uptodate.com/contents/overview-of-androgen-deficiency-and-therapy-in-women

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