Dihydrotestosterone is thought to have fewer effects in women and, as a result, it is believed they are relatively unaffected by having too little dihydrotestosterone. It is possible, however, that the start of puberty may be delayed in girls with too little dihydrotestosterone and the amount of pubic and body hair present in adult females may also be reduced.

In contrast, low levels of dihydrotestosterone in men can have dramatic effects. If there is too little dihydrotestosterone whilst male foetuses are still in the womb, for example, they may not be 'masculinized' and their genitalia may seem similar to that seen in girls of the same age. Later, boys with too little dihydrotestosterone may undergo some of the changes usually seen in puberty (such as muscle growth and production of sperm) but will not develop normal body hair growth and genital development. 
 

Too much dihydrotestosterone, often resulting from excess testosterone production, has variable effects on men and women. It is unlikely that levels of dihydrotestosterone will be raised before the start of puberty. It is also unlikely that adult men with too much dihydrotestosterone would undergo recognizable changes. Women with too much dihydrotestosterone may develop increased body, facial and pubic hair growth (called hirsutism), stopping of menstrual periods (amenorrhoea) and increased acne. Abnormal changes to the genitalia may also occur in women with too much dihydrotestosterone.