Metabolic Health


A healthy result should fall into the range 8.7 - 30.5 nmol/L.

Folates function as cofactors in the transfer and utilization of one carbon groups. These reactions are essential for the production of purines and pyrimidines for DNA synthesis. Folates also play a major role in the regeneration of methionine from homocysteine. In pregnancy, poor body stores of folates may lead to neural tube defects, such as spina bifida. Chronic folate deficiency is often the cause of a megaloblastic anaemia. Certain types of cancers and Alzheimer’s disease have also been linked to reduced folate status.

The predominant form of the vitamin in plasma and red cells is 5-methyltetrahydrofolate (5MTHF). 5MTHF is formed from 5,10-methylenetetrahydrofolate in a reduction reaction, catalysed by methylenetetrahydrofolate reductase (MTHFR). Following synthesis, 5MTHF supplies methyl groups for the remethylation of homocysteine to methionine, hence deficiency of 5MTHF will result in an elevated level of homocysteine, which has been considered to be a cardiovascular risk factor. Different MTHFR polymorphisms have an impact on synthesis of 5MTHF. The base pair substitution of cytosine (C) for thymidine (T) at position 677 reduces the activity of this enzyme.

5-Methyltetrahydrofolate result calculator

insert the value from you 5-Methyltetrahydrofolate test result.

What does it mean if your 5-Methyltetrahydrofolate result is too low?

Decreased MTHFR activity will result in a lower rate of reduction of 5,10-methyleneTHF to 5MTHF. Therefore it possible, that subjects homozygous for MTHFR could have a normal total folate but their synthesis of 5MTHF may not be sufficient to meet metabolic demands of homocysteine metabolism. People who are homozygous for the mutant gene (TT) have homocysteine concentrations about 25% higher than people who are homozygous for the normal gene (CC) or heterozygous (CT), however the increase in homocysteine will also depend on environmental factors such as diet. Research has also shown that deficiency of 5MTHF in red blood cells (RBC) was associated with severity of coronary artery disease and thromboembolism independently of other cardiovascular risk factors or homocysteine.


Are you concerned about your lab report?
Select your plan, upload your lab reports and we’ll provide you with a meaningful interpretation.

Basic Interpretation
  • Instant interpretation
  • Use self upload form
  • 1000+ biomarkers explained
  • Nutrition Recommendations
  • Cancel anytime
Full Interpretation
  • Instant interpretation
  • We upload 4 reports for you
  • 1000+ biomarkers explained
  • Nutrition Recommendations
  • Cancel anytime
  • Online support
Own It For Life
  • Unlimited access
  • No subscription
  • Instant interpretations
  • We upload 10 reports for you
  • 1000+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Test results don't lie. Learn what is happening inside your body.

Health is not exactly rocket science. You just have to know what your body needs and doesn't need. Your medical tests contain that information. Upload them to our service and we’ll help you understand, organize, and act on them.

Get Started

Medical results explained and interpreted. customer review

"I was really concerned about my lab results and my GP was not able to see me for another week. Through HealthMatters I was able to interpret my results instantly." thankfull female customer

"I've been keeping all my lab results in a spreadsheet, covering approximately 20 years. The HealthMatters team helped me upload that info into the cloud. I can show this data to my family and doctors now easily." thankful young female customer

"I had no idea what my lab results meant. Here I found all the biomarkers that I was looking for online. Finally, I have not only organized them all neatly in one place, but I am also grateful to be able to understand what they mean."

Privacy and security of personal data. HIPAA and GDPR compliant badges.

Your Privacy And Security

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put security measures in place to help protect against the loss, misuse or alteration of information under our control. We use procedural, physical and electronic security methods designed to prevent people who aren't authorized from getting access to this information. Our internal code of conduct adds additional privacy protection. See our Privacy Policy for more information.