Estradiol, the most potent of the three primary estrogens (estradiol, estrone, and estriol), plays an essential role in maintaining the health of nearly every tissue in the body, in particular the reproductive tissues, brain, skin, bone, liver, and cardiovascular system. Physiological levels of estradiol formed cyclically with natural progesterone throughout a woman’s premenopausal years maintain the health and youthfulness of these tissues.

Menopause results in the loss of ovarian estrogen production and a consequent drop in circulating levels of estradiol. If, during menopause, estradiol drops well below the lower end seen in premenopausal women, this can be associated with adverse effects in the reproductive tissues (incontinence, vaginal dryness), brain (lowered neurotransmitters, increased hot flashes and night sweats), skin (more rapid aging), bone (accelerated loss and greater risk for osteoporosis and fracture), liver (compromised hormone metabolism and reduced synthesis of hormone binding globulins, reducing the circulating half-lives of hormones that are bound to them), and cardiovascular system (increased risk for insulin resistance, diabetes, and cardiovascular disease).

In a Hormone Metabolite Assessment Panel (HUMAP) for pre-menopausal women, estradiol plays a pivotal role as a primary estrogen hormone. Estradiol is not just a crucial marker for assessing overall estrogenic activity but also for understanding a woman's reproductive health, menstrual cycle regularity, and general well-being.

In pre-menopausal women, estradiol levels fluctuate throughout the menstrual cycle, peaking during ovulation, which signifies the body's readiness for potential conception. These fluctuations are normal and critical for the proper functioning of the reproductive system.

Estradiol, a form of estrogen, is a critical hormone in the human body, primarily responsible for regulating reproductive and sexual health. The Estradiol - Saliva test measures the level of estradiol present in saliva, expressed in picograms per milliliter (pg/mL). Unlike serum tests, saliva testing reflects the bioavailable (free) fraction of estradiol, which is the active form readily used by the body.

Estradiol is the predominant, and the most potent, circulating estrogen. Bioavailable estradiol, which represents about 2% of the total protein-bound estradiol in the bloodstream , exits the bloodstream in capillary beds and enters target cells such as the brain, breasts, uterus, bone and heart.

Please check the reference ranges in the description on the main dashboard as this marker is age and gender specific.

- Estradiol is responsible for the regulation of the estrous and female menstrual reproductive cycles and for the development and maintenance of female secondary sex characteristics.

- Estradiol plays a key role in germ cell maturation and numerous other, non−gender-specific processes, including growth, bone metabolism, nervous system maturation, and endothelial responsiveness.

- Estrogens are crucial for the normal development and maintenance of the breasts and the uterus.

- Excessive estrogen levels, however, can promote cell proliferation and may increase the risk of developing breast and uterine cancers as well as uterine endometriosis.

Estradiol, Ultrasensitive, LC/MS is a highly accurate test that measures very low levels of estradiol (E2)—the most potent form of estrogen—in the male body. This version uses liquid chromatography-tandem mass spectrometry (LC/MS or LC-MS/MS), a gold-standard method for hormone testing, especially when precise measurement at low concentrations is required.

In men, estradiol is mainly produced through the conversion of testosterone via the enzyme aromatase. While estrogen is often thought of as a female hormone, estradiol plays several important roles in male health, including maintaining bone density, supporting mood and cognitive function, regulating libido, and contributing to cardiovascular health.

Has weak estrogen activity. Considered to be a protective estrogen. Most prevalent estrogen in pregnancy.

Estriol is considered to be the mildest and briefest-acting of the three estrogens.

Has weak estrogen activity. Considered to be a protective estrogen. Most prevalent estrogen in pregnancy.

Has weak estrogen activity. Considered to be a protective estrogen. Most prevalent estrogen in pregnancy.

Has weak estrogen activity. Considered to be a protective estrogen. Most prevalent estrogen in pregnancy.

Estriol (E3) is considered to be the mildest and briefest-acting of the three estrogens.

Estrogens play a critical role in female sexual development, menstrual function, protein synthesis, cardiovascular function, bone formation and remodeling, cognitive function, emotional balance and other important health factors.

Has weak estrogen activity. Considered to be a protective estrogen. Most prevalent estrogen in pregnancy.

Has weak estrogen activity. Considered to be a protective estrogen. Most prevalent estrogen in pregnancy.

Has weak estrogen activity. Considered to be a protective estrogen. Most prevalent estrogen in pregnancy.