A healthy result should fall into the range 5 - 18 ng/mg.
The least potent of the estrogens, Estriol (E3) levels are traditionally used clinically to gauge the viability of pregnancies. In the context of this profile, estriol is least likely to be associated with high-estrogen problems (e.g. breast cancer), and is generally viewed as a "protective" estrogen. Conversion of 16alpha-hydroxyestrone to estriol is important to consider. If one is taking a "Bi-Est" or "Tri-Est" preparation, an elevated estriol is not unusual.
Doctors usually test E3 during pregnancy, when it temporarily becomes the main estrogen. Abnormal levels of estriol may be a sign of problems with the baby’s health -- but you’d get a lot more tests to find out for sure. You might need several tests to track changes in your estrogen levels over time.
High estriol implies a potential for elevated 16alpha-hydroxyestrone, a very potent estrogen that is associated with increased risk of breast cancer. There appears to be an association of elevated estriol and elevated 16alpha-hydroxyestrone in patients with systemic lupus erythematosus, implying shifted metabolism in that condition.
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