Optimal Result:
0.5 - 1.7 pg/mL.
Estradiol, the most potent of the three primary estrogens (estradiol, estrone, and estriol), plays an essential role in maintaining the health of nearly every tissue in the body, in particular the reproductive tissues, brain, skin, bone, liver, and cardiovascular system. Physiological levels of estradiol formed cyclically with natural progesterone throughout a woman’s premenopausal years maintain the health and youthfulness of these tissues.
Menopause results in the loss of ovarian estrogen production and a consequent drop in circulating levels of estradiol. If, during menopause, estradiol drops well below the lower end seen in premenopausal women, this can be associated with adverse effects in the reproductive tissues (incontinence, vaginal dryness), brain (lowered neurotransmitters, increased hot flashes and night sweats), skin (more rapid aging), bone (accelerated loss and greater risk for osteoporosis and fracture), liver (compromised hormone metabolism and reduced synthesis of hormone binding globulins, reducing the circulating half-lives of hormones that are bound to them), and cardiovascular system (increased risk for insulin resistance, diabetes, and cardiovascular disease).
Needless to say, estrogens, and specifically estradiol, are essential for maintaining health in both premenopausal and postmenopausal women.
While estradiol plays this significant role in maintaining health, it can also have the opposite effect when certain catechol metabolites are formed in excess and not eliminated properly. Two separate enzymes are involved in converting estradiol and estrone to their respective 2- and 4-catechol derivatives. 2-catechol estrogens are formed by the interaction of the cytochrome enzyme designated CYP1A1. 4-catechol estrogens are formed from CYP1B1. If methylated, both 2- and 4-catechols are essentially rendered inert (harmless), and are excreted in urine. In a healthy individual the formation of estrogens, their beneficial utilization by tissues, and their subsequent elimination in urine and feces are biochemically well coordinated and balanced. However, estradiol and estrone can turn bad in the same way as beneficial oils can go rancid. In fact, the process is very similar and involves oxidation of the estrogens to highly reactive and potentially dangerous metabolites. If these metabolites are not properly channeled down safe pathways of elimination, this could be damaging to some tissues in a way that may eventually be expressed as cancer, most notably breast cancer.
In the presence of excessive reactive oxygen species (ROS) such as peroxylipids, formed mostly from transfats consumed in the diet, the catechol estrogens are further co-oxidized to highly reactive 2- and 4-estrogen quinones. In fact, the reason for avoiding trans-fats to protect the cardiovascular system against damage is the same reason to avoid them to protect the breasts from damage that may lead to breast cancer. ROS such as peroxylipids are very electrophilic (electron hungry) molecules that, under normal circumstances, are inactivated rapidly by interaction with glutathione (the most abundant nucleophilic molecule in tissues, which donates electrons to reactive electrophiles to inactivate them) and glutathione transferase. However, if ROS are in abundance and glutathione levels are low, the highly reactive catechol quinones can bind to DNA, causing mutations that can lead to cancer. 4-quinone estrogens are considered much more dangerous than 2-quinone estrogens because the former cause DNA damage that leads to more permanent (unfixable) mutations (2) that can produce aberrant cancer cells, and given the right circumstances (e.g., a compromised immune system) eventually a breast tumor.
General guide to interpretation:
Lower levels of estradiol and estrone, and higher relative levels of 16-hydroxyestrone and estriol are associated with lower breast cancer risk in postmenopausal women not supplementing with exogenous estrogens (i.e., estrogen replacement therapy). However, this is also dependent on the level of catechol estrogens present, their relative levels (2 vs 4), and how well they are methylated.
If estrogens (estradiol and estrone) are low, as are the catechol estrogens, this would portend a lower risk for breast cancer, but possibly a higher risk for symptoms (e.g., hot flashes), conditions (e.g., bone loss), and diseases (e.g., cardiovascular disease) associated with estrogen deficiency. When estradiol, estrone, and estriol are low, the methylated estrogens would be expected to be low also because of low levels of precursor catechol estrogens. If, however, catechol estrogens are elevated, regardless of the estradiol or estrone level, and methylated estrogens are low, this could indicate higher risk. Keep in mind that the catechol estrogens are not dangerous per se, unless converted to more reactive quinone estrogens. Whether the quinone estrogens damage DNA, or are rapidly inactivated will depend on many factors that are modifiable through diet and nutritional supplements. Excessive dietary consumption of unhealthy trans-fats oxidizes catechol estrogens to more dangerous quinone estrogens, and if glutathione is not present in adequate amounts the quinone estrogens are more likely to damage DNA, and lead to mutations that could be eventually expressed as breast cancer.
Prevention Strategies:
1) Prevention strategies begin with reducing the overall burden of excessive estradiol and estrone in the absence of diminished levels of progesterone, which often occurs in the early phases of menopause (perimenopause-ages 35-55). Progesterone supplementation helps reduce the estrogen burden by increasing the conversion of E2 to E1 (activates 17-beta-hydroxysteroid dehydrogenase), and E1 to E1-sulfate (E1-SO4), an inert form of estrogen that will not enter target cells. 2) 2-hydroxy catechol estrogens are safer than 4-hydroxy catechol estrogens; these are created from the cytochrome enzyme CYP1A1, which is activated by phytochemicals found in cruciferous vegetables (cauliflower, broccoli, cabbage), and by iodine, progesterone, and Vitamin D. If 2-hydroxy catechol estrogens are low, or are low relative to the 4-hydroxy catechol estrogens, consider lowering consumption of meats and increasing consumption of green leafy and cruciferous vegetables.
3) 4-hydroxy catechol estrogens are created from the cytochrome enzyme CYP1B1, which is induced by man-made petrochemical toxins (some drugs, oils, plastics, pesticides, household chemicals, etc.) that contaminate our food, water, and air. If 4-hydroxy catechol estrogens are elevated, consider identifying and avoiding exposure to these petrochemical products as much as possible.
4) As the good (2-OH-catechols) and bad (4-OHcatechols) are both rendered inactive by COMTmediated methylation, it is important to maintain adequate substrates for COMT. These include vitamins B6, B12, and folate, as well as betaine. Excessive estrogens tend to deplete these vitamins, so supplementation during times of estrogen excess (often at perimenopause) is vital to clearing catechol estrogens such that they are less likely to spill over into the highly reactive and mutagenic 4-estrogen quinones.
5) Prevent the conversion of the 2- and 4-catechol estrogens into their respective quinones, and provide adequate substrate to inactivate them if they do. The 2- and 4-catechol estrogens are activated to their quinones by oxidized fats and some heavy metals such as arsenic and mercury. Removal of bad (trans) fats from the diet and countering the heavy metals with adequate beneficial elements such as iodine and selenium are important for preventing further oxidation of estrogen catechols to estrogen quinones.
6) Iodine, progesterone (only when estrogens are within normal to high physiological range of a premenopausal woman), and Vitamin D have all been shown to increase formation of 2-hydroxy catechol estrogens, and decrease the relative concentration of the more dangerous 4-hydroxy catechol estrogens. Consider supplementation if any of these is found to be low by testing.
7) Glutathione is important as the last step in detoxification of quinone estrogens. Excessive medications, hormone therapy, and exposure to environmental toxins such as heavy metals, cigarette smoke and excessive industrial air pollution results in high utilization and lower levels of glutathione. Cysteine is the most limiting amino acid as regards glutathione synthesis, and vitamin C is an essential nutrient for reactivation of oxidized glutathione. Selenium also plays an important role in glutathione’s effectiveness as an anti-oxidant, and low levels of selenium have been associated with higher risks for cancers of the breasts and prostate. If quinone estrogens are elevated, particularly if the methylated catechol estrogens are low, consider foods high in sulfur containing amino acids (allium foods like garlic and onions) and/or supplementation with N-acetylcysteine and Vitamin C. Also consider supplementation with selenium, an essential element in many anti-oxidant enzymes, if it is found to be low.
8) Inadequate production of melatonin has been linked with breast cancer. Melatonin has antiestrogenic actions, acting as a selective estrogen receptor modulator in breast tumor cells, and also downregulating aromatase, thus reducing local estrogen synthesis from androgenic precursors.
Because of the oncostatic effects of melatonin, breast cancer risk can be reduced by getting adequate sleep and/ or reducing exposure to light at night.
References:
Lee JR, Zava D, Hopkins V. What your doctor may not tell you about breast cancer. How hormone balance may save your life. Warner Books, Inc., New York, NY, 2002. Chapter 6.
Cavalieri EL, Rogan EG, Chakravarti D. Initiation of cancer and other diseases by catechol orthoquinones: a unifying mechanism. Cell Mol Life Sci. 2002;59:665-81.
Huang J, Sun J, Chen Y, Song Y, Dong L, Zhan Q, Zhang R, Abliz Z. Analysis of multiplex endogenous estrogen metabolites in human urine using ultra-fast liquid chromatography-tandem mass spectrometry: a case study for breast cancer. Anal Chim Acta. 2012;711:60-8.
Getoff N, Gerschpacher M, Hartmann J, Huber JC, Schittl H, Quint RM. The 4-hydroxyestrone: Electron emission, formation of secondary metabolites and mechanisms of carcinogenesis. J Photochem Photobiol B. 2010 Jan 21;98(1):20-4.
Arslan AA, Shore RE, Afanasyeva Y, Koenig KL, Toniolo P, Zeleniuch-Jacquotte A. Circulating estrogen metabolites and risk for breast cancer in premenopausal women. Cancer Epidemiol Biomarkers Prev. 2009;18:2273-9.
Obi N, Vrieling A, Heinz J, Chang-Claude J. Estrogen metabolite ratio: Is the 2-hydroxyestrone to 16α-hydroxyestrone ratio predictive for breast cancer? Int J Womens Health. 2011;3:37-51.
Falk RT, Brinton LA, Dorgan JF, Fuhrman BJ, Veenstra TD, Xu X, Gierach GL. Relationship of serum estrogens and estrogen metabolites to postmenopausal breast cancer risk: a nested casecontrol study. Breast Cancer Res. 2013;15:R34.
Fuhrman BJ, Schairer C, Gail MH, Boyd-Morin J, Xu X, Sue LY, Buys SS, Isaacs C, Keefer LK, Veenstra TD, Berg CD, Hoover RN, Ziegler RG. Estrogen metabolism and risk of breast cancer in postmenopausal women. J Natl Cancer Inst. 2012;104:326-39.
Cos S, Gonzalez A, Martínez-Campa C, et al. Estrogen-signaling pathway: a link between breast cancer and melatonin oncostatic actions. Cancer Detect Prev. 2006;30:118-28.
High estradiol in premenopausal women is usually caused by excessive production of androgens (testosterone and DHEA) by the ovaries and adrenal glands, which are converted to estrogens by the ‘aromatase’ enzyme found in adipose (fat) tissue. When estrogen levels are high in postmenopausal women, this is usually due to estrogen supplementation or slow clearance from the body (sluggish liver function). Excess estrogen levels, especially in combination with low progesterone, may lead to the symptoms of “estrogen dominance,” including: mood swings, irritability, anxiety, water retention, fibrocystic breasts, weight gain in the hips, bleeding changes (due to overgrowth of the uterine lining and uterine fibroids) and thyroid deficiency. Estradiol, even at normal, premenopausal levels, can cause estrogen dominance symptoms if not balanced by adequate progesterone. Diet, exercise, nutritional supplements, cruciferous vegetable extracts, herbs and foods that are natural aromatase inhibitors and bioidentical progesterone can help to reduce the estrogen burden and symptoms, naturally.
Import lab results from multiple providers, track changes over time, customize your reference ranges, and get clear explanations for each result. Everything is stored securely, exportable in one organized file, and shareable with your doctor—or anyone you choose.
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Low estradiol in premenopausal women is unusual unless they experience an anovulatory cycle (no ovulation) or are supplementing with birth control pills, which can suppress endogenous (made in the body) production of estrogens by the ovaries. A low estradiol level is much more common in postmenopausal women or in women of any age who have had their ovaries surgically removed (oophorectomy) and/or those who have not been treated with hormone replacement. Symptoms and conditions commonly associated with estrogen deficiency include hot flashes, night sweats, sleep disturbances, foggy thinking, vaginal dryness, incontinence, thinning skin, bone loss, and heart palpitations.
Laboratories
We accept reports from any lab, so you can easily collect and organize all your health information in one secure spot.
Pricing Table
Choose the plan that fits you — and turn scattered lab reports into clear insights you can finally use.
Pick a plan that fits you — and turn scattered lab reports into clarity.
Personal plans
Professional plan
$15/ month
Access your lab reports, explanations, and tracking tools.
$250/ once
Pay once, access everything—no monthly fees, no limits.
Professional plan
$45/ month
Designed for professionals managing their clients' lab reports
About membership
Import Lab Results from Any Source
Easily upload lab results from any provider, whether it's a hospital, independent lab, or home testing service. We support PDFs, scanned documents, and JPEGs from patient portals. No need to log in to multiple platforms — everything is centralized in one secure space.
Easily upload lab results from any provider — we support PDFs, scans, and images. Keep all your reports organized in one secure place.
See Your Health Timeline
Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey. Whether you're tracking a condition, managing treatments, or staying proactive, the timeline helps you and your doctor understand how things progress over time.
Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey.
Understand What Your Results Mean
Whether it's a blood test, GI panel, urinalysis, or something else, lab reports measure numerous biomarkers that reveal what's happening inside your body. Our extensive database covers over 10,000 biomarkers, providing clear, simple explanations of what each result means and how you can take action—no matter your membership level. Say goodbye to confusion and get the insights you need to better understand your health.
Our database covers over 10,000 biomarkers with clear, simple explanations—so you can finally understand your results and what to do next.
Enter Your Lab Reports Yourself — Always Free
Enter Your Lab Reports — Always Free
If you'd like to handle inputting your health data into your account, you can do so with our easy-to-use data entry forms. Our user-friendly form is designed to guide you through the quick and easy submission process, making it simple to keep track of your health metrics. This is available to both Complete plan and Unlimited plan members.
Our user-friendly form guides you through a quick, simple submission process, making it easy to enter your health metrics.
Add your results anytime with our easy entry form. It's quick, guided, and helps you stay organized — free for all members.
Visualize Your Results
View your lab data through easy-to-read graphs and tables. Quickly spot patterns, track changes, and compare results across different dates — all without digging through multiple reports. You can also select and compare graphs of specific biomarkers side-by-side to better understand how they relate and change over time.
See your lab reports in clear graphs and tables. Spot patterns, track changes, and compare results over time — all in one place.
Export Your Complete Lab History in a Single File
Export Your Complete Lab History
After collecting lab results from different providers, you can download your entire history combined into a single file. Choose from PDF, Excel, or CSV formats to easily review, share, or get a second opinion—no more juggling multiple reports.
After collecting lab results from different providers, you can download your entire history combined into a single file.
Comprehensive Data Entry Service for Your Reports
Data Entry Service for Your Reports
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest. Complete plan members receive one report entered for free, then $15 per report after that. Unlimited plan members receive ten report entries for free, then $15 per report after that.
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest.
Securely Share With Anyone You Trust
Whether you're working with a doctor, nutritionist, caregiver, or wellness coach, you can securely share your complete lab history by sending an invite link to anyone you trust. You have full control over who sees your information and for how long, ensuring your privacy and peace of mind at every step.
Share your full lab history with your doctor, nutritionist, or coach using a secure invite link.
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I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Anthony
Unlimited Plan Member since 2021
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Karin
Advanced Plan Member since 2020
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
Paul
Healthmatters Pro Member since 2024
Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
With a Healthmatters account, you can:
Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you're on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
The Complete Plan ($15/month) is perfect for individuals who want ongoing access to their health data. It includes unlimited lab imports, visual tracking, custom ranges, result explanations, full account exports, and secure sharing — all with a simple monthly subscription. You can cancel anytime and restart your plan whenever you're ready — your data will still be there waiting for you. You can also upgrade to the Unlimited Plan at any time, with the cost prorated based on what you've already paid.
The Unlimited Plan ($250 one-time) is also designed for individuals but offers lifetime access with no ongoing subscription. You'll get all the same features as the Complete Plan, plus a larger initial data entry allowance (10 reports), making it a great choice if you prefer a one-time payment and long-term use without monthly fees.
In short:
There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
Prefer to do it yourself? You can always use our free self-entry tool to add results manually — it just takes a bit more time and attention.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
The Pro Monthly Plus plan is priced at $75 per month and includes a data entry service for five reports each month. Additional reports can be self-entered at no extra cost or, if preferred, you can use our data entry service for an additional fee of $15 per report.
The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
You also have the option to upgrade to higher monthly or to annual plans, which come with substantial discounts. All upgrades can be done directly from your account.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewExplore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Yes, you can download your information anytime. We offer two easy ways to export your lab data:
This makes it simple to save, back up, or share your health data whenever you need.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
