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Total Glutathione

Optimal Result: 373 - 838 uM.

Total Glutathione in Whole Blood - Glutathione is a tripeptide formed by a peptide linkage between the amine group of cysteine linked to glycine and the carboxyl group of the glutamate side-chain.

It is an abundant cellular reducing agent, whose major biological function is mitigating oxidative damage to biological macromolecules.

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Glutathione is an antioxidant, a type of chemical which helps to boost your immune system as well as prevent and reverse cellular damage. Unlike most antioxidants which come from the food you eat, glutathione is naturally produced by the body in the liver. Glutathione plays a number of roles in overall health including boosting the immune system, helping to break down nutrients in food, and protecting against chronic diseases such as Alzheimer's, Parkinsons, diabetes, some types of cancer, and heart disease. Glutathione levels tend to decrease naturally with age as well as due to health conditions such as liver disease, insomnia, and chronic stress. 

- Glutathione is composed of cysteine, glutamine & glycine. Glutathione is a source of sulfate and plays a key role in antioxidant activity and detoxification of toxins.

- Glutathione is the most abundant and important intracellular antioxidant.

- Glutathione in erythrocytes is an indicator of intracellular Glutathione status, the overall health of cells and of the ability to endure toxic challenges. 

- Glutathione is involved in many biological processes including detoxification of xenobiotics, removal of oxygen-reactive species, regulation of the redox state of cells and the oxidative state of important protein sulfhydryl groups, and regulation of immune function.

What does it mean if your Total Glutathione result is too high?

GSH requirement is increased with high-fat diets, cigarette smoke, cystinuria, chronic alcoholism, chronic acetaminophen use, infection, inflammation and toxic exposure.

Some factors that result in increased biosynthesis and "high normal" GSH levels include, but are not limited to, moderate alcohol consumption, smoking, regular physical exercise and acute exposure to toxic metals. Under such conditions it is essential to provide the body with the key nutrients involved in GSH synthesis in order to sustain functionally appropriate levels of GSH. Magnesium and potassium are required for both energy-dependent enzymatic steps in GSH synthesis, and cysteine is the rate limiting amino acid. Nutritional products that have been documented to increase erythrocyte GSH/GSH biosynthesis include α-lipoic acid, curcumin, oral liposomal GSH, nebulized GSH, and to a lesser extent, N-acetyl-L-cysteine.

Assessing and supporting appropriately high levels of GSH is important for protecting cells and promoting overall health and longevity, and contributes significantly to safe and effective metal detoxification.

High levels of glutathione have also been linked to chemotherapy resistance in cancer treatments.

What does it mean if your Total Glutathione result is too low?

Glutathione is also important in the metabolism and excretion of xenobiotic compounds. Glutathione is consumed to maintain cells in a reduced condition. Consequently, glutathione levels in patient samples are expected to be diminished in disease states where oxygen reactive species are involved, such as rheumatoid arthritis and atherosclerosis. Low glutathione levels have been linked to reduced dopamine production in neurons, which suggests a relationship to dopamine based neurological disorders such as parkinson's disease.

Low GSH contributes to oxidative stress and is thus a risk factor for many chronic diseases.

Deficiency may result in:

- oxidative stress & damage,

- impaired detoxification,

- altered immunity,

- macular degeneration

- and increased risk of chronic illness.

Low levels of GSH have been reported in:

- cardiovascular disease,

- cancer,

- AIDS,

- autism,

- alcoholism

- and debilitating neurodegenerative diseases such as Alzhiemer's and Parkinson's.

It has also been associated with chronic retention of potential toxic elements such as:

- mercury,

- lead,

- arsenic,

- cadmium,

- manganese

- and iron,

- as well as chemicals and some drugs.

Intracellular GSH biosynthesis and intracellular levels can be upregulated as a protective mechanism.

Glutathione levels tend to decrease naturally with age as well as due to health conditions such as liver disease, insomnia, and chronic stress. 

Frequently asked questions

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With a Healthmatters account, you can dive into the details of each biomarker and gain insights into the meaning behind your medical test data, anytime, anywhere.

For our professional users, Healthmatters provides intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history.

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You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.

If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.

While we work with many popular labs, we welcome reports from lots of other places too.

It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.

If you’re on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.

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Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.

For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.

We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.

Our special data entry service makes it easy to add your results to your private dashboard. Just attach an image or a file of your lab test results, and our skilled data entry team will do the work for you. It's all done by humans, ensuring that your data is entered accurately and with personal care for each client.

Depending on your account, the data entry service can be included for free or come at an additional cost of $15 per report.

For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.

Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.

Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.

The Unlimited plan is a one-time purchase for $250, and it covers your account for a lifetime with no additional payments.

For the Complete plan, the cost is $15 per month. You have the flexibility to cancel it anytime through your account settings, ensuring no further payments. To avoid charges, remember to cancel at least a day before the renewal date. Once canceled, the subscription remains active until the end of the current billing cycle.

Additionally, you can upgrade to the yearly Advanced plan from within your account. The annual cost is $79, and it comes with a data entry service for five reports.

You can always upgrade to a lifetime version with a prorated price from a monthly or yearly subscription.

Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.

Our goal has been to make your Healthmatters account as intuitive as possible.

We’ve crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.

1. Graph View:

Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.

2. All Tests View

Explore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.

3. Table View:

For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.

Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.

Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.

Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.

Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.

A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.

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To learn more about Healthmatters Pro, please refer to the professional page.

Yes, you can! Simply go to the "Invite Doctor" section, enter your doctor’s email address, and send the invitation. Your doctor will receive an email with secure access to view your results. You can revoke this access at any time. All shared information is securely encrypted and protected for your privacy.
Yes, you can! Go to the Graph view or Spreadsheet view. In the top-right corner, click "Export to Excel," and the file will be downloaded to your device.

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