Beta-Hydroxybutyrate (BHB) is a ketone body extensively measured in clinical diagnostics to assess and monitor ketosis and ketogenic states. BHB is produced in the liver from fatty acids during periods of low carbohydrate intake, fasting, prolonged exercise, or in pathological states such as diabetes mellitus. As a water-soluble molecule, BHB circulates throughout the body and can be utilized by various tissues, including the brain, as an alternative energy source when glucose availability is limited.
The measurement of BHB is critical in identifying and managing conditions associated with altered metabolic states, such as diabetic ketoacidosis (DKA), a serious complication of diabetes characterized by the combination of hyperglycemia, ketosis, and acidosis. Elevated levels of BHB in the bloodstream are indicative of insulin deficiency and the body's shift towards fat metabolism, leading to an accumulation of ketones and a decrease in blood pH.
In clinical practice, the quantification of BHB serves not only as a diagnostic marker for DKA but also as an important tool in the management of individuals following ketogenic diets, those with suspected alcohol intoxication, and patients at risk of starvation ketosis. It provides a more accurate reflection of the ketotic state compared to other ketone bodies (acetone and acetoacetate) due to its stability in the bloodstream. Treatment for elevated BHB levels focuses on addressing the underlying cause: in the case of DKA, this involves fluid replacement, electrolyte supplementation, and insulin therapy to reverse the ketotic state and restore normal metabolic function. For individuals on a ketogenic diet or experiencing fasting-induced ketosis, monitoring BHB levels can help ensure that ketosis remains within a safe and therapeutic range.
Keeping track of your medical data and laboratory results while understanding what they mean empowers positive health outcomes.
Keeping track of your medical data and lab results while understanding what they mean empowers positive health outcomes.
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Elevated levels of Beta-Hydroxybutyrate (BHB) in the blood are indicative of the body's increased reliance on fat for energy instead of glucose, a state known as ketosis. This condition can occur under various circumstances, such as fasting, adherence to a ketogenic diet, prolonged exercise, or more critically, diabetic ketoacidosis (DKA) in individuals with diabetes.
In the context of DKA, high BHB levels signal a dangerous shift in metabolism due to insulin deficiency, leading to excessive ketone production, blood acidification, and potentially life-threatening complications if not addressed promptly.
For individuals following a ketogenic diet or experiencing fasting-induced ketosis, elevated BHB levels are generally expected and can be a sign of successful diet adherence, contributing to weight loss and potential therapeutic effects for neurological conditions. However, monitoring is essential to ensure levels remain within a safe range to avoid negative health impacts.
Treatment and management strategies differ based on the underlying cause of elevated BHB levels. In cases of diabetic ketoacidosis, urgent medical treatment is required, typically involving intravenous fluids to hydrate the body, electrolyte supplements to balance blood chemistry, and insulin therapy to reduce blood glucose levels and halt excessive ketone production. For those on ketogenic diets, ensuring nutritional balance and possibly adjusting dietary intake can help manage BHB levels. Regular monitoring under medical supervision is recommended for individuals with diabetes or those at risk of high ketone levels to prevent complications and ensure overall health and safety.
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Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we do talk about popular labs, we welcome reports from lots of other places too. It's as simple as this: if you can get a test done, you can upload it to Healthmatters. We can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
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Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you. We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
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Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.
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21-Hydroxylase Antibodies, Acetoacetate, S/P, Acetylcholine Receptor Ganglionic (Alpha 3) AB, Adamts13 Activity, Alpha 2 Antiplasmin, Ana Pattern, AnaChoice Screen, Arachidonic Acid, B2 GLYCOPROTEIN I (IGA)AB, B2 GLYCOPROTEIN I (IGG)AB, B2 GLYCOPROTEIN I (IGM)AB, Beta 2 Transferrin, Beta-Hydroxybutyrate, Copeptin, CORTISOL,FREE,LC/MS,S, DNA Ab (ds) Crithidia, IFA, EPA/ARACHIDONIC ACID Ratio, ESTRADIOL (Quest), G-6-PD, RBC, GLUCOSE-6-PHOSPHATE DEHYDROGENASE, Glutamic Acid Decarboxylase 65 AB, Gluten (F79) IgG, Helicobacter Pylori, Urea Breath Test, Hexagonal Phase Confirm, HISTAMINE, PLASMA, IGF 1, LC/MS, IMMUNOGLOBULIN M, Immunoglobulin Subclass 4, Lactic Acid, Plasma, LH, Lithium, LKM-1 Antibody (IgG), LUPUS ANTICOAGULANT, Metanephrine, Free, Mutated Citrullinated Vimentin (MCV) Ab, Neuron Specific Enolase (NSE), Normetanephrine, Free, NT PROBNP, OH-Hexanoylcarnitine, C6OH, OMEGA 3 (EPA+DHA) INDEX, OMEGA 6/OMEGA 3 Ratio, Parathyroid Hormone, intact, PARTIAL THROMBOPLASTIN TIME, ACTIVATED, PREGNENOLONE, LC/MS, PROGESTERONE, LC/MS, Prostaglandin D2 (PG D2), Urine, Prostaglandin E2, Serum/Plasma, PROSTAGLANDINS (PG D2), SERUM/PLASMA, PROSTAGLANDINS: (PLASMA/SERUM), PROTHROMBIN ANTIBODY (IGG), Selenium, Soluble Liver Antigen (SLA) Autoantibody, T3 Reverse, LC/MS/MS, T3, FREE, Total Glutathione, Total, Free (MN+NMN), TRYPTASE, TSI - Thyroid-Stimulating Immunoglobulin, Serum, Vascular Endothelial Growth Factor (VEGF), Z SCORE (FEMALE), Z SCORE (MALE)
