AnaChoice Screen

Blood

Reference range:

The ANAchoice Screen is a diagnostic test used to detect the presence of antinuclear antibodies (ANA) in the blood. ANAs are a group of antibodies that bind to certain contents of the nucleus of the cell and are often found in patients with certain autoimmune diseases, such as systemic lupus erythematosus (SLE), Sjögren's syndrome, and rheumatoid arthritis, among others.

When an ANAchoice Screen is conducted, it typically includes an initial screening assay for connective tissue disease disorders. If this screening test is positive, indicating that high levels of ANA are present, it will reflex to additional tests for specific antibodies to further identify the disease. This reflex testing involves more specific assays to determine the titer (concentration) and pattern of the ANA, which can provide more detailed information helpful in diagnosing certain autoimmune diseases.

The method commonly used for ANA screening is an immunofluorescence assay (IFA) performed on human epithelial type 2 (HEp-2) cells. This method is particularly helpful in the diagnosis of systemic lupus erythematosus (SLE), but it is also a part of the initial diagnostic evaluation in individuals with a clinical suspicion of autoimmune diseases associated with ANAs.

If the ANAchoice Screen is positive, other tests, such as the double-stranded DNA (ds-DNA) test, may be performed at an additional charge. The ds-DNA test is particularly associated with systemic lupus erythematosus (SLE) and provides further clarification on the patient's condition.

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