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Quest Diagnostics Quest Diagnostics

Selenium

Serum
Optimal Result: 63 - 160 mcg/dL.

 

Selenium, a trace element essential for human health, plays a critical role in various physiological processes and is commonly assessed through its concentration in serum. As an integral component of selenoproteins, selenium is pivotal in antioxidant defense systems, thyroid hormone metabolism, and immune function. The primary dietary sources of selenium include nuts, cereals, meat, fish, and eggs, with its bioavailability influenced by soil composition and dietary factors. Serum selenium levels are reflective of both short-term and long-term selenium status, offering a reliable biomarker for nutritional assessment. The typical reference range for serum selenium varies, but is generally considered to be between 70 and 150 ng/mL. Deficiencies in selenium can lead to adverse health outcomes such as Keshan disease, a cardiomyopathy, and Kashin-Beck disease, an osteoarthropathy. Conversely, excessive selenium intake can result in selenosis, characterized by symptoms including gastrointestinal disturbances, hair loss, and neurological abnormalities. Analytical methods for determining serum selenium levels include atomic absorption spectrometry, particularly hydride generation atomic absorption spectrometry, and inductively coupled plasma mass spectrometry, both offering high sensitivity and specificity. Monitoring serum selenium is crucial in various clinical settings, particularly in regions with known soil selenium deficiencies or in populations with dietary restrictions, to prevent both deficiency and toxicity, thereby ensuring optimal health outcomes.

Reference Range(s):

<2 Years 16-71 mcg/L
2-4 Years 40-103 mcg/L
4-16 Years 55-134 mcg/L
Adult 63-160 mcg/L

What does it mean if your Selenium result is too high?

Elevated levels of selenium in the serum indicate an excessive intake of this trace element, a condition known as selenosis. This overexposure can occur due to high dietary intake from selenium-rich foods, such as certain nuts and seafood, or through over-supplementation. Environmental exposure in areas with selenium-rich soil can also contribute to higher levels. Selenosis can manifest in various symptoms including gastrointestinal problems, hair and nail loss, fatigue, irritability, and in severe cases, neurological issues. The treatment for selenosis primarily involves reducing or eliminating the source of excess selenium. This might mean adjusting the diet to avoid selenium-rich foods or discontinuing selenium supplements. In cases where environmental exposure is a factor, it may require relocating or implementing measures to reduce contact with selenium-rich soils or water. Additionally, supportive care to manage symptoms, such as providing nutritional support for hair and nail growth, might be necessary. It's important to work closely with a healthcare provider for proper diagnosis and to tailor a treatment plan that addresses the specific cause and symptoms of the elevated selenium levels. Regular monitoring of serum selenium levels can help in tracking the effectiveness of these interventions and ensuring that levels return to a safe range.

What does it mean if your Selenium result is too low?

Low levels of selenium in the serum indicate a deficiency in this essential trace element, which can arise from inadequate dietary intake, poor absorption, or increased requirements due to certain health conditions. Selenium deficiency can have significant health implications as it is crucial for the proper functioning of the immune system, thyroid gland, and antioxidant defenses in the body. Symptoms of selenium deficiency can include muscle weakness, fatigue, hair loss, and a weakened immune system. In more severe cases, it can lead to specific conditions like Keshan disease, a type of heart disease, or Kashin-Beck disease, a type of osteoarthritis.

Treatment for selenium deficiency primarily involves increasing selenium intake. This can be achieved through dietary adjustments, focusing on selenium-rich foods such as seafood, nuts (especially Brazil nuts), meats, cereals, and dairy products. In cases where dietary changes are insufficient or impractical, selenium supplements may be used. It is important that supplementation be done under medical supervision to avoid the risk of overdosing, as excessive selenium intake can lead to toxicity. Additionally, addressing any underlying conditions that might be contributing to poor selenium absorption or increased requirements is crucial. Regular monitoring of serum selenium levels can help to ensure that the treatment is effective and that levels are being restored to a healthy range.

Frequently asked questions

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