Quest Diagnostics

Soluble Liver Antigen (SLA) Autoantibody

Optimal Result: 0 - 20.1 u.

Anti-soluble liver antigen antibodies are detected in 10% - 30% of patients with type 1 autoimmune hepatitis (AIH), but not in patients with type 2 AIH, primary sclerosing cholangitis or primary biliary cirrhosis.

What is type 1 autoimmune hepatitis (AIH)?

Autoimmune hepatitis occurs when the body's immune system, which ordinarily attacks viruses, bacteria and other pathogens, instead targets the liver. This attack on your liver can lead to chronic inflammation and serious damage to liver cells. Just why the body turns against itself is unclear, but researchers think autoimmune hepatitis could be caused by the interaction of genes controlling immune system function and exposure to particular viruses or drugs.

Type 1 autoimmune hepatitis is the most common type of this disease. It can occur at any age. About half the people with type 1 autoimmune hepatitis have other autoimmune disorders, such as celiac disease, rheumatoid arthritis or ulcerative colitis.

What does it mean if your Soluble Liver Antigen (SLA) Autoantibody result is too high?

Anti-soluble liver antigen antibodies are detected in 10% - 30% of patients with type 1 autoimmune hepatitis (AIH), but not in patients with type 2 AIH, primary sclerosing cholangitis or primary biliary cirrhosis.

Type 1 autoimmune hepatitis is the most common type of this disease. It can occur at any age. About half the people with type 1 autoimmune hepatitis have other autoimmune disorders, such as celiac disease, rheumatoid arthritis or ulcerative colitis.

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