The adrenal 21-hydroxylase antibody test also referred to as the adrenal antibodies test, is used to investigate the insufficiency of the adrenal gland and to assess the risk that a person may develop an autoimmune adrenal gland insufficiency.
This result is a qualitative determination of autoantibodies to 21-Hydroxylase (21-OH Abs) in patient serum. 21-OH Abs occur in autoimmune Addison's disease, whether isolated or part of type I or type II autoimmune polyglandular syndrome. This result should be used in conjunction with other clinical and laboratory findings and is not a substitute for functional testing required to diagnose adrenal insufficiency.
--------------------------------
Cortisol, aldosterone, and other steroid hormones are secreted by the adrenal glands. Cortisol and aldosterone are vital hormones, and an adrenal gland malfunction, known as Addison's disease, should be quickly detected and treated.
Our immune system is responsible for our body's defense against cell and foreign organism threats. Often, some of its tissues are deregulated and mistaken for foreign matter. Antibodies produced against the body's tissues are the cause of a large number of autoimmune diseases, including juvenile diabetes, rheumatoid arthritis, and several thyroid disorders. Auto-antibodies are also the most common cause of Addison's disease, either alone or often in combination with other autoimmune conditions (hypothyroidism, pernicious anemia, type 1 diabetes, etc.).
The presence of 21-hydroxylase antibodies is consistent with developing or established Addison's disease.
Potential symptoms:
Over time, adrenal insufficiency or Addison's disease may lead to these symptoms:
- Inability to digest food, loss of appetite, and weight loss
- Chronic fatigue and muscle weakness
- Blotchy, dark tanning and freckling of the skin; this is most noticeable on parts of the body exposed to the sun, but also occurs in unexposed areas like the gums. Darkened skin is particularly likely to occur on the forehead, knees, and elbows or along scars, skin folds, and creases (such as on the palms).
- Low blood pressure (hypotension) that falls further when standing; this causes dizziness, sometimes to the point of fainting.
- Nausea, vomiting, and diarrhea
- Blood sugar abnormalities, including dangerously low blood sugar (hypoglycemia)
- Moodiness, irritability, and depression
- Inability to cope with stress
- Craving for salty foods
- Intolerance to heat or cold
Interpret Your Lab Results
Upload your lab report, and we'll interpret and provide you with recommendations today.
Get StartedMonthly plan
Annual plan
Own it for life
Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
$15 /month
billed every month
Most popular
Data entry included
$79 /year
$6.60/month billed annually
Data entry included
$250 /once
own it for life
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Monthly Plus
for health professionals
$75 per month
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
21-Hydroxylase Antibodies, Acetylcholine Receptor Ganglionic (Alpha 3) AB, Adamts13 Activity, Alpha 2 Antiplasmin, Ana Pattern, B2 GLYCOPROTEIN I (IGA)AB, B2 GLYCOPROTEIN I (IGG)AB, B2 GLYCOPROTEIN I (IGM)AB, Beta 2 Transferrin, CARNITINE ESTERS, Carnitine, Free, Carnitine, Total, CHROMOGRANIN A, COPEPTIN, Cortisol, Free, Urine, CORTISOL,FREE,LC/MS,S, DNA Ab (ds) Crithidia, IFA, ESTERIFIED/FREE RATIO, ESTRADIOL (Quest), GLUCOSE-6-PHOSPHATE DEHYDROGENASE, Glutamic Acid Decarboxylase 65 AB, Helicobacter Pylori, Urea Breath Test, HISTAMINE RELEASE (CHRONIC URTICARIA), HISTAMINE, PLASMA, IGF 1, LC/MS, IMMUNOGLOBULIN M, Immunoglobulin Subclass 4, LH, Lithium, LKM-1 Antibody (IgG), LUPUS ANTICOAGULANT, Neuron Specific Enolase (NSE), NT PROBNP, Parathyroid Hormone, intact, PARTIAL THROMBOPLASTIN TIME, ACTIVATED, PREGNENOLONE, LC/MS, PROGESTERONE, LC/MS, PROSTAGLANDIN D2 (PG D2), URINE, Prostaglandin E2, Serum/Plasma, PROSTAGLANDINS (PG D2), SERUM/PLASMA, PROSTAGLANDINS: (PLASMA/SERUM), PROTHROMBIN ANTIBODY (IGG), Ribosomal P Antibody, Soluble Liver Antigen (SLA) Autoantibody, T3 REVERSE, LC/MS/MS, T3, FREE, Total Glutathione, TRYPTASE, TSI - Thyroid-Stimulating Immunoglobulin, Serum, Vascular Endothelial Growth Factor (VEGF), Z SCORE (FEMALE), Z SCORE (MALE)