Double-Stranded DNA (dsDNA) Antibody, IgG by IFA (using Crithidia luciliae).
→ Positivity for anti-double stranded DNA (anti-dsDNA) IgG antibody is a diagnostic criterion of systemic lupus erythematosus (SLE).
Note on testing: Some patients with early or inactive SLE may be positive for anti-dsDNA IgG by ELISA but negative by CLIFT. If the CLIFT result is negative but the patient has a positive ELISA and clinical suspicion remains, consider antinuclear antibody (ANA) testing by IFA. Additional information and recommendations for testing may be found at https://arupconsult.com/content/connective-tissue-diseases.
This test may not be used independently for monitoring treatment response or establishing remission.
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