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Research Gluten (F79) IgG
Quest Diagnostics Quest Diagnostics

Gluten (F79) IgG

Optimal Result: 0 - 2 mcg/mL.

Gluten (F79) IgG is a specific immunoglobulin G antibody marker used in the immunological assessment of gluten sensitivity and related disorders. This antibody targets a fraction of gluten proteins, primarily found in wheat and related grains, and its presence in the bloodstream can be indicative of an immune response to gluten ingestion. Unlike IgA antibodies, which are more commonly associated with celiac disease, IgG antibodies are not typically specific to celiac but rather suggest a broader gluten sensitivity or intolerance. High levels of Gluten (F79) IgG antibodies may be present in individuals with non-celiac gluten sensitivity (NCGS), a condition characterized by gastrointestinal and extraintestinal symptoms related to gluten ingestion, without the autoimmune or allergic mechanisms of celiac disease or wheat allergy. The testing for Gluten (F79) IgG is crucial for distinguishing between these conditions, as the management and dietary modifications differ significantly. Moreover, this marker is valuable in monitoring the immune response in individuals who have already adopted a gluten-free diet, as it helps assess the effectiveness of dietary compliance and changes. However, the interpretation of Gluten (F79) IgG levels should be approached with caution, as elevated levels can also occur in other conditions and even in healthy individuals without gluten-related disorders, thus necessitating a comprehensive clinical assessment alongside serological testing.

What does it mean if your Gluten (F79) IgG result is too high?

Elevated levels of Gluten (F79) IgG antibodies generally indicate that the body's immune system is responding to gluten, a protein found in wheat, barley, and rye. This response is not the same as in celiac disease, which involves a different type of antibody and an autoimmune process. Instead, high levels of Gluten (F79) IgG are often associated with non-celiac gluten sensitivity (NCGS). Individuals with NCGS may experience symptoms like abdominal pain, bloating, diarrhea, or even extra-intestinal symptoms such as headaches, joint pain, or fatigue when they consume gluten-containing foods. It's important to note that elevated Gluten (F79) IgG levels can sometimes be found in people without any obvious symptoms or gluten intolerance, so the results should be interpreted in the context of clinical symptoms.

In terms of treatment, the primary approach for managing elevated Gluten (F79) IgG levels, especially when symptomatic for gluten sensitivity, is a gluten-free diet. This involves avoiding all foods that contain gluten, including many types of bread, pasta, cereals, and processed foods unless they are specifically labeled as gluten-free. It's recommended to consult with a dietitian to ensure that the gluten-free diet is well-balanced and nutritionally adequate. In some cases, symptoms might improve within a few weeks of starting a gluten-free diet. However, for some individuals, it may take longer to see a significant change in symptoms and antibody levels. Regular follow-up with healthcare providers and periodic retesting may be necessary to monitor the response to dietary changes and ensure overall health and nutritional adequacy.

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