The Vascular Endothelial Growth Factor (VEGF) test measures the amount of VEGF in your blood.
VEGF is a protein that stimulates the growth of new blood vessels — a process known as angiogenesis. It’s produced by your body when tissues aren’t getting enough oxygen, helping restore blood flow and oxygen supply to those areas.
VEGF plays a vital role in normal body functions, including:
Supporting blood vessel formation after injury or exercise
Aiding bone formation and the creation of new blood cells
Maintaining healthy circulation in organs like the lungs and brain
However, too much VEGF can contribute to disease processes, particularly cancer and vascular conditions.
Many tumors rely on VEGF to grow. As cancer cells multiply, they release VEGF to build new blood vessels that feed them oxygen and nutrients.
High VEGF levels are often linked to faster tumor growth, metastasis (spread to other areas), and sometimes a poorer prognosis.
Because of this, several cancer therapies are designed to block VEGF activity, effectively starving tumors of their blood supply. Measuring VEGF levels can help doctors monitor how well these treatments are working.
VEGF doesn’t just promote vessel growth—it can also make blood vessels leakier. This can cause fluid buildup and swelling in tissues.
Examples include:
Brain cancers, where VEGF-induced swelling can raise intracranial pressure
Eye diseases such as diabetic retinopathy and age-related macular degeneration, where VEGF-driven vessel leakage can damage vision
VEGF has also been studied in neurodegenerative disorders (like Alzheimer’s and ALS), where abnormal VEGF signaling may contribute to nerve cell damage.
The VEGF test is especially valuable for diagnosing and monitoring POEMS syndrome, a rare condition marked by:
Polyneuropathy (nerve damage)
Organomegaly (enlarged organs)
Endocrinopathy (hormonal problems)
Monoclonal gammopathy (abnormal antibody production)
Skin changes
VEGF levels are typically very elevated in POEMS syndrome, helping distinguish it from other causes of neuropathy or plasma cell disorders.
Normal VEGF levels, however, do not rule out POEMS syndrome.
Low oxygen (hypoxia) stimulates VEGF production to restore tissue oxygenation.
High VEGF levels may indicate tumor activity, inflammation, or POEMS syndrome.
Low VEGF levels have been associated with some neurological and psychiatric conditions, including depression and Alzheimer’s disease.
The VEGF test helps assess how your body regulates blood vessel growth and oxygen supply.
It’s mainly used to:
Evaluate or confirm POEMS syndrome
Monitor cancer treatment response
Investigate unexplained vascular or neurological symptoms
Melincovici CS, Bosca AB, Susman S, Marginean M, Mihu C, Istrate M, Moldovan IM, Roman AL, Mihu CM. Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis. Rom J Morphol Embryol. 2018;59(2):455-467. PMID: 30173249.
Storkebaum E, Carmeliet P. VEGF: a critical player in neurodegeneration. J Clin Invest. 2004 Jan;113(1):14-8. doi: 10.1172/JCI20682. PMID: 14702101; PMCID: PMC300888.
Mateo I, Llorca J, Infante J, Rodríguez-Rodríguez E, Fernández-Viadero C, Peña N, Berciano J, Combarros O. Low serum VEGF levels are associated with Alzheimer's disease. Acta Neurol Scand. 2007 Jul;116(1):56-8. doi: 10.1111/j.1600-0404.2006.00775.x. PMID: 17587256.
Isung, J., Aeinehband, S., Mobarrez, F. et al. Low vascular endothelial growth factor and interleukin-8 in cerebrospinal fluid of suicide attempters. Transl Psychiatry 2, e196 (2012). https://doi.org/10.1038/tp.2012.123
Isung J, Mobarrez F, Nordström P, Asberg M, Jokinen J. Low plasma vascular endothelial growth factor (VEGF) associated with completed suicide. World J Biol Psychiatry. 2012 Sep;13(6):468-73. doi: 10.3109/15622975.2011.624549. Epub 2011 Nov 18. PMID: 22098148.
Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F, Marklund SL, Wyns S, Thijs V, Andersson J, van Marion I, Al-Chalabi A, Bornes S, Musson R, Hansen V, Beckman L, Adolfsson R, Pall HS, Prats H, Vermeire S, Rutgeerts P, Katayama S, Awata T, Leigh N, Lang-Lazdunski L, Dewerchin M, Shaw C, Moons L, Vlietinck R, Morrison KE, Robberecht W, Van Broeckhoven C, Collen D, Andersen PM, Carmeliet P. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet. 2003 Aug;34(4):383-94. doi: 10.1038/ng1211. PMID: 12847526.
Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 1996 Apr 4;380(6573):435-9. doi: 10.1038/380435a0. PMID: 8602241.
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Elevated circulating concentrations of vascular endothelial growth factor (VEGF) may be observed in a variety of disease states, especially those associated with angiogenesis. Elevated concentrations of VEGF must be interpreted within the clinical context of the patient.
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As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
Low VEGF levels mean your body may be producing less of the protein responsible for building and repairing blood vessels. VEGF delivers oxygen and nutrients to vital tissues like the brain, nerves, and muscles, helping them heal and function properly. When VEGF drops too low, tissues may receive less blood flow, which can affect healing, energy, and nerve health.
VEGF is your body’s natural “construction signal” for new blood vessels — a process called angiogenesis. It ensures oxygen and nutrients reach every cell, especially in high-demand areas such as the brain, spinal cord, muscles, and eyes. Even a 50% drop in VEGF can significantly limit your ability to grow and repair blood vessels.
When VEGF levels stay low:
Blood flow to nerves can decline, depriving them of oxygen.
Nerve cells lose VEGF’s protective and regenerative effects, making them more vulnerable to damage.
Muscle weakness and atrophy may develop over time if motor neurons are affected.
Research also suggests VEGF helps regulate vascular tone by influencing nitric oxide release and autonomic nerve function — meaning low VEGF might impair your body’s ability to adjust blood flow when needed.
Scientific studies have connected low VEGF levels with several neurological and mood-related conditions:
Alzheimer’s disease: People with Alzheimer’s often have lower VEGF in blood and cerebrospinal fluid, suggesting decreased vessel repair and nutrient delivery in the brain.
Amyotrophic lateral sclerosis (ALS): Reduced VEGF has been linked to increased ALS risk and faster nerve degeneration. VEGF supports motor neuron survival by improving spinal cord blood flow and providing protective signals.
Depression and suicidality: Lower VEGF levels are more common in severe depression and among individuals with a history of suicide attempts.
Nerve and muscle weakness: Low VEGF may contribute to chronic oxygen shortage (ischemia) and progressive nerve damage.
POEMS syndrome: Unlike most conditions, VEGF is usually elevated in this rare disorder. A drop over time may indicate treatment success.
Low VEGF alone cannot diagnose any particular disease, but it can offer insight into tissue health and nerve function. If your VEGF levels are low, work with your healthcare provider to:
Review medications (especially anti-VEGF therapies or steroids) that may lower VEGF.
Assess nutrition and metabolism, including protein intake, B vitamins, and oxygen delivery.
Check for neurological or vascular symptoms like tingling, numbness, weakness, or brain fog.
Repeat the test after addressing possible causes to see if levels remain low.
VEGF supports healthy blood vessels, nerve protection, and tissue repair.
Low VEGF may be associated with neurodegenerative or mood disorders but does not confirm them on its own.
Improving circulation, reducing inflammation, and addressing nutrient deficiencies may help support VEGF balance naturally.
Always interpret VEGF results with your healthcare provider, considering symptoms and other test findings.
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Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
Healthmatters is a highly-personalized health dashboard.
Instead of searching for your lab results in different places or tracking them down from different providers, Healthmatters houses, organizes, and interprets them all in one central location.
With a Healthmatters account, you can dive into the details of each biomarker and gain insights into the meaning behind your medical test data, anytime, anywhere.
For our professional users, Healthmatters provides intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history.
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
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If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you’re on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
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Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
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We’ve crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
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21-Hydroxylase Antibodies, Acetoacetate, S/P, Acetylcholine Receptor Ganglionic (Alpha 3) AB, Adamts13 Activity, Alpha 2 Antiplasmin, Ana Pattern, AnaChoice Screen, Arachidonic Acid, B2 GLYCOPROTEIN I (IGA)AB, B2 GLYCOPROTEIN I (IGG)AB, B2 GLYCOPROTEIN I (IGM)AB, Beta 2 Transferrin, Beta-Hydroxybutyrate, CD15S EXPRESSION (LAD 2), CD18 EXPRESSION (LAD 1), Copeptin, DNA Ab (ds) Crithidia, IFA, EPA/ARACHIDONIC ACID Ratio, ESTRADIOL (Quest), Fungitell® (1-3)-ß-D-Glucan Assay, G-6-PD, RBC, GLUCOSE-6-PHOSPHATE DEHYDROGENASE, Glutamic Acid Decarboxylase 65 AB, Gluten (F79) IgG, Helicobacter Pylori Ag, EIA, STOOL, Helicobacter Pylori, Urea Breath Test, Hexagonal Phase Confirm, HISTAMINE, PLASMA, IMMUNOGLOBULIN M, Immunoglobulin Subclass 4, Lactic Acid, Plasma, LH, Lithium, LKM-1 Antibody (IgG), LUPUS ANTICOAGULANT, Metanephrine, Free, Mutated Citrullinated Vimentin (MCV) Ab, Neuron Specific Enolase (NSE), Neutrophil Antibody, Flow Cytometry - Neutrophil Antibody, Normetanephrine, Free, NT PROBNP, OH-Hexanoylcarnitine, C6OH, OMEGA 3 (EPA+DHA) INDEX, OMEGA 3 (EPA+DHA) INDEX (numer.), OMEGA 6/OMEGA 3 Ratio, Parathyroid Hormone, intact, PARTIAL THROMBOPLASTIN TIME, ACTIVATED, Penicillium Chrysogenum/notatum IgG, PREGNENOLONE, LC/MS, PROGESTERONE, LC/MS, Prostaglandin D2 (PG D2), Urine, Prostaglandin E2, Serum/Plasma, PROSTAGLANDINS (PG D2), SERUM/PLASMA, PROSTAGLANDINS: (PLASMA/SERUM), PROTHROMBIN ANTIBODY (IGG), Risk (of cardiovascular disease), Selenium, Soluble Liver Antigen (SLA) Autoantibody, T3 Reverse, LC/MS/MS, T3, FREE, Total Glutathione, Total, Free (MN+NMN), TRYPTASE, TSI - Thyroid-Stimulating Immunoglobulin, Serum, Vascular Endothelial Growth Factor (VEGF)
