The Manganese (Mn) content in the adult human is 11.0 to 23 ng/mL. About 25% is stored in the skeleton. Within each cell, Manganese is concentrated in the mitochondria. Bone, liver, and pancreas tend to have the highest concentrations.
Mn is an important part of the anti-oxidant enzyme super oxidase dismutase.
Manganese deficiency produces growth disorders, alters skeletal and cartilage formation, and impairs reproduction.
Deficiency symptoms are unclear. There may be blood clotting defects, hypocholesterolemia, elevated serum calcium, phosphorus, and alkaline phosphatase. There may be loss of muscle tone, diabetes, and heart disease.
Manganese is an essential trace element involved in various physiological processes, including metabolism, bone development, and antioxidant function. Elevated levels of manganese in red blood cells can indicate excessive exposure to manganese, possibly due to occupational or environmental factors such as certain industrial work, mining, or contaminated air or water. Chronic exposure to high levels of manganese has been linked to neurological effects, including neurobehavioral changes, cognitive impairments, and movement disorders. Monitoring manganese levels in red blood cells is crucial in assessing potential toxicity and implementing appropriate measures to reduce exposure and prevent associated health risks.
Treatment for elevated manganese levels in red blood cells primarily focuses on reducing further exposure to manganese and managing symptoms if present. Here are some key approaches:
Identify and minimize exposure: Identify the sources of manganese exposure and take necessary steps to minimize contact. This may involve workplace safety measures or lifestyle adjustments to avoid contaminated environments.
Medical monitoring: Regular medical monitoring to assess the levels of manganese in the body is crucial for early detection and intervention. Healthcare providers may conduct blood or urine tests to monitor manganese levels and evaluate the effectiveness of treatment.
Symptomatic treatment: If symptoms of manganese toxicity are present, symptomatic treatment may be necessary. This could involve addressing neurological symptoms through various therapies, including occupational therapy, speech therapy, and physical therapy, depending on the specific symptoms and their severity.
Dietary modifications: Dietary adjustments may help reduce manganese intake. Consulting with a healthcare provider or nutritionist to create a balanced diet with reduced manganese content can be beneficial.
Chelation therapy: In severe cases, chelation therapy might be considered to remove excess manganese from the body. However, this treatment option is typically reserved for extreme cases and should be administered under the supervision of a qualified healthcare professional.
It's crucial to consult with a healthcare provider for an individualized treatment plan based on the severity of manganese toxicity and the specific symptoms exhibited.
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