The Interleukins belong to the family termed cytokines. They are peptides used by immune and inflammatory cells to communicate and control cell operations.
The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells. Interleukin-8 is a glycoprotein produced primarily by macrophages and monocytes. Its primary target cells are neutrophils.
Interleukin-8 is a chemotactic agent for monocytes and neutrophils. Interleukin 8 causes oxygen radical and enzyme release by neutrophils and mobilizes products into circulation. Interleukin 8 is stimulated by Interleukin 1 and Tumor Necrosis Factor.
Interleukin 8 (IL-8) is a promising marker for many clinical conditions and currently being applied by various subspecialties of medicine either for the purpose of rapid diagnosis or as a predictor of prognosis. Nevertheless, IL-8 level increased as a result of many inflammatory conditions, so careful interpretation of IL-8 level is required to make correlation with desired clinical condition's diagnosis or prognosis.
IL-8 is involved in neutrophil activation, and is released from several cell types in response to inflammation, including monocytes, macrophages, neutrophils, and intestine, kidney, placenta, and bone marrow cells. It is a member of the beta-thromboglobulin superfamily and is structurally related to platelet factor 4. IL-8 is involved in mitogenesis, inhibition of angiogenesis, inflammation, chemotaxis, neutrophil degranulation, leukocyte activation, and calcium homeostasis.
Promising use of interleukin 8 (IL-8) in various fields of medicine:
|Urology and Nephrology||Marker for chronic prostatitis|||
|Marker for acute pyelonephritis|||
|Hematology||Marker for non-Hodgkin's lymphoma|||
|Oncology||Marker for urinary bladder cancer|||
|Therapeutic target to control cancer growth and metastasis|||
|Pediatrics||Marker for nasocomial bacterial infections in neonatal intensive care unit (NICU)||[15, 16]|
|Marker for vesicoureteral reflux (VUR).|||
|Microbiology||Detection of pulmonary infections|||
|Detection of osteomyelitis|||
|Nuclear Medicine||99mTc-labeled IL-8 scintigraphy for diagnosis of clinical conditions|||
High levels of IL-8 are reported in chronic inflammatory diseases such as gout, coronary artery disease, rheumatoid arthritis and inflammatory bowel disease (IDB).
Own it for life
Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
billed every month
Data entry included
$6.60/month billed annually
Data entry included
own it for life
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Monthly Plus
for health professionals
$75 per month