Anti-C1q autoantibodies are indicative for lupus nephritis, but can also be found in other conditions and inflammatory diseases.
Circulating immune complexes can be demonstrated in rheumatic, infectious, and neoplastic diseases, as well as most immunologically mediated illnesses (inflammatory bowel disease, thrombotic thrombocytopenic purpura). Complement is part of the innate immune system. Its major function is recognition and elimination of pathogens. Complement activity plays also an important role in the pathogenesis of systemic autoimmune diseases. It is activated amongst others by CIC in the blood stream. In the process of complement activation split products like C3d can be detected in patients suffering lupus nephritis or in patients with cutaneous systemic scleroderma. Patients with systemic autoimmune diseases might also develop antibodies targeting components of the complement cascades. One of the important components that is been targeted is C1q.
Why is this test important?
C1q can assist to monitor immune complex disease (ie, lupus, glomerulonephritis, serum hepatitis, arthritis, vasculitis) or to monitor progress of some malignancies.
Circulating immune complexes may be found without any evident pathology and positive results do not necessarily implicate the immune complex in a disease process.
References:
Siegert CE, Kazatchkine MD, Sjöholm A, Würzner R, Loos M, Daha MR. Autoantibodies against C1q: view on clinical relevance and pathogenic role. Clin Exp Immunol. 1999 Apr;116(1):4-8. doi: 10.1046/j.1365-2249.1999.00867.x. PMID: 10209498; PMCID: PMC1905233.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get your interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
Anti-C1q autoantibodies are indicative for lupus nephritis, but can also be found in other conditions and inflammatory diseases.
Circulating immune complexes can be demonstrated in rheumatic, infectious, and neoplastic diseases, as well as most immunologically mediated illnesses (inflammatory bowel disease, thrombotic thrombocytopenic purpura). Complement is part of the innate immune system. Its major function is recognition and elimination of pathogens. Complement activity plays also an important role in the pathogenesis of systemic autoimmune diseases.
Interpret Your Lab Results
Upload your lab report, and we'll interpret and provide you with recommendations today.
Get StartedMonthly plan
Annual plan
Own it for life
Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
$15 /month
billed every month
Most popular
Data entry included
$79 /year
$6.60/month billed annually
Data entry included
$250 /once
own it for life
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Monthly Plus
for health professionals
$75 per month
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
ACE, Serum, Acetone, Blood, Activated Protein C Resistance, Ammonia, Plasma, ANA by IFA Rfx Titer/Pattern, ANA Direct, ANA Pattern, Androstenedione LCMS, Anti GAD 65 Antibodies, Anti-DNase B Strep Antibodies, Anti-histone Abs, Anti-intermyofibrillar, Anti-sarcolemma, Antiadrenal Antibodies, Quant, Antinuclear Antibodies, IFA, Antistreptolysin O Ab, B-Type Natriuretic Peptide, Babesia duncani WA1 IgG IFA, C difficile Toxins A+B, EIA, Carbon Monoxide, Blood, Cold Agglutinin Titer, Quant, Copper, RBC, Dehydroepiandrosterone (DHEA), Ethanol, Blood, F078-IgG Casein, F079-IgG Gluten, F2-Isoprostane/Creatinine, Fats, Neutral, Fats, Total, Folate, Hemolysate, Folate, RBC, G-6-PD, Quant, G6PD, Galectin-3, Hexagonal Phospholipid Neutral, Histamine Determination, Blood, Immune Complexes, C1q Binding, Interleukin-8, Serum, Isopropanol, Blood, K080-IgE Formaldehyde, Lactic Acid, Plasma, M-Spike, Manganese, Plasma, Manganese, RBC, Melanocyte-stimulating Hormone (MSH), Methanol, Blood, Mono Qual W/Rflx Qn, Neopterin, Serum, NT-proBNP, Platelet Neutralization, Propeptide Type I Collagen, Protein C-Functional, RNP Antibodies, Rubella Antibodies, IgG, Serotonin, Serum, Sirolimus (Rapamune), Blood, Strongyloides IgG Antibody, Testost., F+W Bound, Thyroxine Binding Globulin, Toxoplasma gondii Ab, IgG, Treponema pallidum Antibodies, Valproic Acid (Depakote), Serum, Varicella Zoster IgG, Vasoactive Intestinal Polypeptide (VIP), Plasma, Zinc Protoporphyrin (ZPP), ZnT8 Antibodies