3-O-Methyldopa

Plasma
Optimal Result: 50 - 145 nmol/L.

3-O-Methyldopa (3-OMD) is a compound that emerges in the context of diagnosing and monitoring various medical conditions, particularly those related to neurological disorders such as Parkinson's disease. It's essential to understand that 3-OMD is closely related to L-DOPA, a medication widely used in the treatment of Parkinson's disease. In patients receiving L-DOPA therapy, 3-OMD is produced as a metabolite - a substance created during the breakdown and conversion of the drug within the body. 

The presence and levels of 3-O-Methyldopa in the body can be significant for several reasons. For patients undergoing treatment with L-DOPA, measuring 3-OMD levels can help in monitoring the efficacy of the treatment and in adjusting dosages to achieve optimal therapeutic effects. Elevated levels of 3-OMD might suggest that the body is metabolizing L-DOPA more into 3-OMD than is ideal, which could lead to adjustments in treatment to improve outcomes. Furthermore, understanding the levels of 3-O-Methyldopa can also contribute to the broader understanding of a patient's metabolic processes and the possible need for adjustments in therapeutic strategies.

If the concentraton of 3-O-methyldopa in plasma is within the reference range, it demonstrates that the individual does not have aromatc L-amino acid decarboxylase (AADC) defciency.

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