Proline is a nonessential amino acid, which means that it is manufactured from other amino acids in the liver; it does not have to be obtained directly through the diet.
Proline is the precursor to hydroxyproline, which is a major amino acid found in the connective tissue of the body – collagen.
– Its effect in human nutrition, other than as a source of nitrogen, is not well established.
– Supplementation with proline has not been found to increase collagen formation.
– Proline is found in virtually every dietary protein except lactalbumin. Although proline is not classified as an essential amino acid, proline levels in plasma are dramatically reduced with a proline-free diet.
– Proline is a major constituent of collagen and can be metabolized to alpha-KG, which is important in ammonia detoxification and the citric acid cycle.-
– Hyperprolinemia is a recognized genetic disorder characterized by renal and central nervous system dysfunction.
– Vitamin C and iron are known cofactors in the conversion to hydroxyproline and may be useful if connective tissue symptoms are present. Acute or chronic deficiency of vitamin C produces a significant increase in the proline/hydroxyproline ration in urine.
– The relationship between proline and hydroxyproline urinary excretion has been used as an index of collagen catabolism.
References:
– Low plasma levels of proline reflect low tissue supply of this amino acid. As proline is a major component of collagen, low plasma level can mean defective connective tissue synthesis. Alpha-KG could be used to normalize the value.
– Low proline levels can indicate a low protein diet and may prevent optimal connective tissue maintenance.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get your interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
– Proline is universally required to protein synthesis and is metabolized to hydroxyproline, an important component in connective tissue. Therefore, high levels may reflect inadequate connective tissue synthesis. Proline can also be oxidized to glutamic acid, requiring niacin as a cofactor precursor.
– Higher levels of proline can demonstrate poor utilization. Add vitamin C to aid collagen synthesis if symptoms present. Niacin (cofactor precursor) helps oxidize proline to glutamate.
– High levels of proline and hydroxyproline may be lowered by supplementing vitamin C and Iron.
– Consistently high levels of proline can potentially be due to a genetic condition called Hyperprolinemia. Levels of blood proline levels can be 3 to 15 times higher than normal levels. [L]
Interpret Your Lab Results
Upload your lab report, and we'll interpret and provide you with recommendations today.
Get Started
Monthly plan
Annual plan
Own it for life
Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
$15 /month
billed every month
Most popular
Data entry included
$79 /year
$6.60/month billed annually
Data entry included
$250 /once
own it for life
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Monthly Plus
for health professionals
$75 per month
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
1-Methylhistidine (Plasma), 3-Methylhistidine (Plasma), Alanine (Plasma), Alpha-Amino-n-butyric acid (Plasma), Alpha-Aminoadipic Acid (Plasma), Alpha-ANB/Leucine, Anserine (Plasma), Arginine (Plasma), Asparagine (Plasma), Aspartic Acid (Plasma), Beta-Alanine, Beta-Aminoisobutyric Acid (Plasma), Carnosine (Plasma), Citrulline, Cystathionine (Plasma), Cystine, Ethanolamine (Plasma), g-Aminobutyric Acid (Plasma), Glutamic Acid (Plasma), Glutamic Acid/Glutamine, Glutamine (Plasma), Glycine (Plasma), Histidine (Plasma), Homocysteine (Genova), Homocystine (Genova), Hydroxylysine (Genova), Hydroxyproline (Genova), Hydroxyproline/Proline (Genova), Isoleucine (Plasma), Leucine (Plasma), Lysine (Plasma), Methionine (Plasma), Ornithine (Genova), Phenylalanine (Plasma), Phenylalanine/Tyrosine (Genova), Phosphoethanolamine (Plasma), Phosphoserine (Plasma), Proline (Plasma), Sarcosine (Plasma), Serine (Plasma), Taurine (Plasma), Threonine (Plasma), Tryptophan (Plasma), Tryptophan/LNAA (Genova), Tyrosine (Plasma), Valine (Plasma)
