Genova: Amino Acids 40 Profile - Plasma

Proline (Plasma)

Optimal Result: 99 - 363 µmol/L, or 9.90 - 36.30 µmol/dL.

Proline is a nonessential amino acid, which means that it is manufactured from other amino acids in the liver; it does not have to be obtained directly through the diet.

Proline is the precursor to hydroxyproline, which is a major amino acid found in the connective tissue of the body – collagen.

– Its effect in human nutrition, other than as a source of nitrogen, is not well established.

– Supplementation with proline has not been found to increase collagen formation.

– Proline is found in virtually every dietary protein except lactalbumin. Although proline is not classified as an essential amino acid, proline levels in plasma are dramatically reduced with a proline-free diet.

– Proline is a major constituent of collagen and can be metabolized to alpha-KG, which is important in ammonia detoxification and the citric acid cycle.-

– Hyperprolinemia is a recognized genetic disorder characterized by renal and central nervous system dysfunction.

– Vitamin C and iron are known cofactors in the conversion to hydroxyproline and may be useful if connective tissue symptoms are present. Acute or chronic deficiency of vitamin C produces a significant increase in the proline/hydroxyproline ration in urine.

– The relationship between proline and hydroxyproline urinary excretion has been used as an index of collagen catabolism.

References:

https://ghr.nlm.nih.gov/condition/hyperprolinemia

What does it mean if your Proline (Plasma) result is too low?

– Low plasma levels of proline reflect low tissue supply of this amino acid. As proline is a major component of collagen, low plasma level can mean defective connective tissue synthesis. Alpha-KG could be used to normalize the value.

– Low proline levels can indicate a low protein diet and may prevent optimal connective tissue maintenance.

What does it mean if your Proline (Plasma) result is too high?

– Proline is universally required to protein synthesis and is metabolized to hydroxyproline, an important component in connective tissue. Therefore, high levels may reflect inadequate connective tissue synthesis. Proline can also be oxidized to glutamic acid, requiring niacin as a cofactor precursor.

– Higher levels of proline can demonstrate poor utilization. Add vitamin C to aid collagen synthesis if symptoms present. Niacin (cofactor precursor) helps oxidize proline to glutamate.

– High levels of proline and hydroxyproline may be lowered by supplementing vitamin C and Iron.

– Consistently high levels of proline can potentially be due to a genetic condition called Hyperprolinemia. Levels of blood proline levels can be 3 to 15 times higher than normal levels. [L]

10 000+ happy clients
100% satisfaction
★ ★ ★ ★ ★ customer support

Understand blood, stool, and urine medical results from all your laboratories.

Get Started With Our Personal Plan

Advanced Plan

  • ✓ Yearly subscription
  • ✓ Five free uploads
  • ✓ Cancel anytime
  • ✓ Instant interpretations
  • ✓ Use the free self-upload form
  • ✓ 3000+ biomarkers explained
  • ✓ Nutrition Recommendations
  • ✓ Dedicated support
  • ✓ Yearly subscription
  • ✓ Five free uploads
  • ✓ Cancel anytime
$79 per year
  • ✓ Instant interpretations
  • ✓ Use the free self-upload form
  • ✓ 3000+ biomarkers explained
  • ✓ Nutrition Recommendations
  • ✓ Dedicated support

Unlimited Plan

  • ✓ No subscription
  • ✓ Ten free uploads
  • ✓ Unlimited access
  • ✓ Instant interpretations
  • ✓ Use the free self-upload form
  • ✓ 3000+ biomarkers explained
  • ✓ Nutrition Recommendations
  • ✓ Dedicated support
  • ✓ No subscription
  • ✓ Ten free uploads
  • ✓ Unlimited access
$250 full version

Are You a Health Professional?

Get started with our professional plan

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more

Pro Plan

for health professionals

  • ✓ Track multiple clients results
  • ✓ No setup fees
  • ✓ No hidden costs
  • ✓ Cancel anytime
  • ✓ Instant interpretations
  • ✓ Use the free template forms
  • ✓ 3000+ biomarkers explained
  • ✓ Additional team member $25
  • ✓ Personal training and support

$45 per month

Use promo code to save 10% off any plan.


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

×

Understand Your Lab Result Now

  • Instant interpretation
  • 3000+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode: