Homocystine is a common amino acid in your blood. You get it mostly from eating meat. High levels of it are linked to early development of heart disease.
A homocystine test measures the amount of homocystine in your blood plasma. Normally, vitamin B12, vitamin B6, and folic acid break down homocystine and change it into other substances your body needs. There should be very little homocystine left in the bloodstream. If you have high levels of homocystine in your blood, it may be a sign of a vitamin deficiency, heart disease, or a rare inherited disorder.
– High levels in body fluids of homocystine have been associated with increased risk of cardiovascular disease as well as ocular, neurological, musculoskeletal and joint abnormalities.
– Meat contains substances that cause an increase in homocystine levels, which in turn is associated with increased risk of heart disease. High homocystine levels irritate the lining of arteries, increasing the likelihood that they will clog, whereas the folate and vitamin b6 found in vegetables and grains reduce homocystine levels.
– It has been shown in epidemiological studies that elevated levels of homocystine in the plasma is one of 3 major risk factors in dementia or Alzheimer’s. The other 2 factors are the APOE4 genotype and a decreased DHA plasma level.
– Homocystine is deemed to be a direct vascular toxin that hastens arterial blockages, not only to the coronary arteries of the heart, but also to the arteries to the brain, leading to almost 2 times higher risk of dementia.
– Moderately elevated levels of homocystine are associated with a significantly increased risk of atherosclerosis.
– Elevated homocystine tends to coincide with high homocysteine.
– The enzyme that converts homocysteine (reduced homocystine) to cystathionine is B6 dependent; remethylation of homocysteine to methionine requires B12, folate and betaine.
– High levels can (very rarely) be due to Homocystinuria: A rarebiochemical abnormality characterized by the abnormal presence of homocystine in the blood and urine. It is caused by any of several enzyme deficiencies in the metabolic pathway of methionine to cystine. The disease is inherited as an autosomal-recessive trait. Its clinical signs are similar to those of Marfan’s syndrome, including intellectual disability, osteoporosis leading to skeletal abnormalities, dislocated lenses, and thromboembolism.
Treatment may include a diet low in methionine and supplementation with high doses of vitamin B6. Long-term results of treatment are not available.
Possible treatment options for high levels that are not genetic:
– Follow a strict plant-based (=vegan) diet that is high in green leafy vegetables, fruits, grains and legumes.
– Make sure to have enough B6, Folate, B12, Betaine and magnesium as those are effective for the proper metabolism of homocystine. However, getting your homocystine levels down with vitamins doesn’t reduce your chance of having heart disease.
Own it for life
Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
billed every month
Data entry included
$6.60/month billed annually
Data entry included
own it for life
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Monthly Plus
for health professionals
$75 per month