A healthy result should fall into the range 3 - 14 nmol/ML.

Homocysteine is a sulphur-containing amino acid and is an intermediate metabolite of methionine metabolism.

Homocysteine is a well-known cardiovascular disease risk factor.

– Metabolized by two pathways; trans-methylation and trans-sulphation pathways.
– Regulation of homocysteine depends on certain key nutrients, including vitamin B12, vitamin B6 and folic acid.
– High homocysteine levels are an important biomarker in risk assessment for CVD, strokes and other inflammatory diseases.
– Functional biomarker for low B6, B9 and B12; also excess methionine.
– It may also give indications of polymorphisms affecting methylation

Age, gender, folate, serum vitamin B12, serum creatinine and multivitamin usage are determinants of plasma homocysteine concentration. In population studies, total plasma homocysteine concentrations are higher in men than in women, increase markedly with age and are inversely correlated with blood folate, serum vitamin B12 and serum creatinine. Users of multivitamins have a lower homocysteine levels than nonusers.

References:

  1. https://www.merckmanuals.com/professional/hematology-and-oncology/thrombotic-disorders/hyperhomocysteinemia#v12779073
  2. https://www.ncbi.nlm.nih.gov/pubmed/10063987
  3. https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(03)00438-1/fulltext
  4. https://www.karger.com/Article/Abstract/326301
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935890/
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321271/
  7. https://www.nejm.org/doi/full/10.1056/NEJMoa032739
  8. https://repub.eur.nl/pub/8452
  9. https://www.ahajournals.org/doi/10.1161/01.ATV.21.1.74

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