A healthy result should fall into the range 3 - 14 nmol/ML.

Homocysteine is a sulphur-containing amino acid and is an intermediate metabolite of methionine metabolism.

Homocysteine is a well-known cardiovascular disease risk factor.

– Metabolized by two pathways; trans-methylation and trans-sulphation pathways.
– Regulation of homocysteine depends on certain key nutrients, including vitamin B12, vitamin B6 and folic acid.
– High homocysteine levels are an important biomarker in risk assessment for CVD, strokes and other inflammatory diseases.
– Functional biomarker for low B6, B9 and B12; also excess methionine.
– It may also give indications of polymorphisms affecting methylation

Age, gender, folate, serum vitamin B12, serum creatinine and multivitamin usage are determinants of plasma homocysteine concentration. In population studies, total plasma homocysteine concentrations are higher in men than in women, increase markedly with age and are inversely correlated with blood folate, serum vitamin B12 and serum creatinine. Users of multivitamins have a lower homocysteine levels than nonusers.

References:

  1. https://www.merckmanuals.com/professional/hematology-and-oncology/thrombotic-disorders/hyperhomocysteinemia#v12779073
  2. https://www.ncbi.nlm.nih.gov/pubmed/10063987
  3. https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(03)00438-1/fulltext
  4. https://www.karger.com/Article/Abstract/326301
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935890/
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321271/
  7. https://www.nejm.org/doi/full/10.1056/NEJMoa032739
  8. https://repub.eur.nl/pub/8452
  9. https://www.ahajournals.org/doi/10.1161/01.ATV.21.1.74

Homocysteine (Genova) result calculator

insert the value from you Homocysteine (Genova) test result.

What does it mean if your Homocysteine (Genova) result is too low?

Although high plasma homocysteine is widely recognized as a cardiovascular disease risk factor, individuals with low homocysteine are also at risk of other conditions related to sulfur amino acid metabolism. The risk of hypohomocysteinemia derives from the fact that homocysteine is the normal precursor for formation of cysteine and thus production of glutathione, taurine and sulfate from methionine. 

Individuals with low homocysteine have limited capacity for up-regulation of glutathione synthesis in response to oxidative stress and certain kinds of toxin exposure. The most common treatment for low homocysteine is administration of sulfur-containing amino acids such as N-acetylcysteine and taurine. Preformed glutathione and inorganic sulfate salts (postassium salts) may also be employed to support hepatic and renal demands for toxin removal through sulfation and mercaptan formation. 

Hypohomocysteinemia causes reduced availability of cysteine. Cysteine restriction causes limitation in production of sulfate, taurine and glutathione. The limited production ability is exacerbated in conditions that cause increased demand for any of the sulfur compounds produced from homocysteine, such as alcohol intake.

What does it mean if your Homocysteine (Genova) result is too high?

The most common dietary deficiency leading to homocysteine elevation and the associated increase in heart disease risk involves vitamin B12 and folic acid. You can have normal blood levels of these vitamins but still not have enough for your body’s enzymes to function properly. Dietary deficiency of vitamin B12 and folic acid are associated with increased risk of many diseases, including anemia and the associated chronic fatigue.

Vitamin B6 deficiency may also result in elevated concentrations of homocysteine in blood, which leads to increased risk of heart disease.

A high level of homocysteine in the blood (hyperhomocysteinemia) makes a person more prone to endothelial cell injury, which leads to inflammation in the blood vessels, which in turn may lead to atherogenesis, which can result in ischemic injury. Abnormally high levels of homocysteine in the serum, above 15 µmol/L, are a medical condition called hyperhomocysteinemia.

Hyperhomocysteinemia is a possible risk factor for coronary artery disease. Coronary artery disease occurs when an atherosclerotic plaque blocks blood flow to the coronary arteries, which supply the heart with oxygenated blood.

High levels of homocysteine can also be a risk factor for the development of a wide range of diseases, including thrombosis, neuropsychiatric illness, and fractures.

Are you concerned about your lab report?
Select your plan, upload your lab reports and we’ll provide you with a meaningful interpretation.

Basic Interpretation
  • Instant interpretation
  • Use self upload form
  • 800+ biomarkers explained
  • Nutrition Recommendations
  • Cancel anytime
Full Interpretation
  • Instant interpretation
  • We upload 4 reports for you
  • 800+ biomarkers explained
  • Nutrition Recommendations
  • Cancel anytime
  • Online support
Own It For Life
  • Unlimited access
  • No subscription
  • Instant interpretations
  • We upload 10 reports for you
  • 800+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Test results don't lie. Learn what is happening inside your body.

Health is not exactly rocket science. You just have to know what your body needs and doesn't need. Your medical tests contain that information. Upload them to our service and we’ll help you understand, organize, and act on them.

Get Started

Medical results explained and interpreted.

WE SUPPORT 1000+ BIOMARKERS INCLUDING BIOMARKERS FROM YOUR FAVOURITE LABS

Healthmatters.io customer review

"I was really concerned about my lab results and my GP was not able to see me for another week. Through HealthMatters I was able to interpret my results instantly."

Healthmatters.io thankfull female customer

"I've been keeping all my lab results in a spreadsheet, covering approximately 20 years. The HealthMatters team helped me upload that info into the cloud. I can show this data to my family and doctors now easily."

Healthmatters.io thankful young female customer

"I had no idea what my lab results meant. Here I found all the biomarkers that I was looking for online. Finally, I have not only organized them all neatly in one place, but I am also grateful to be able to understand what they mean."



Pricing
Privacy and security of personal data. HIPAA and GDPR compliant badges.

Your Privacy And Security

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put security measures in place to help protect against the loss, misuse or alteration of information under our control. We use procedural, physical and electronic security methods designed to prevent people who aren't authorized from getting access to this information. Our internal code of conduct adds additional privacy protection. See our Privacy Policy for more information.