Genova: Amino Acids 40 Profile - Plasma

Phenylalanine/Tyrosine (Genova)

A healthy result should fall into the range 0 - 1.44 Ratio.

The Phenylalanine/Tyrosine Ratio evaluates the body’s ability to convert phenylalanine to tyrosine; Conversion enzyme requires tetrahydrobiopterin (BH4), niacin (B3), and iron as cofactors.

Elevations in the serum Phenylalanine/Tyrosine Ratio have potential value for estimating the presence of an inflammatory disease and the catabolic state of a person.

This marker is also routinely used to screen newborns for phenylketonuria, an inborn error of metabolism that results in decreased metabolism of phenylalanine. This results in the buildup of dietary phenylalanine to potentially toxic levels. Not sufficient, because other causes of hyperphenylalaninemia (eg, BH4 deficiency) cannot be excluded by this test alone.

Phenylalanine is one of the amino acids, which are important nutrients that we get from our diets. Amino acids are used by the body to make protein which is essential for most physiological processes. Amino acids also serve as precursors to be converted by enzymes into other important compounds for the brain and other organs.

The metabolic pathway here is the conversion of phenylalanine into tyrosine. The importance of this pathway is that it removes excess phenylalanine and it enables the production of sufficient tyrosine. Tyrosine is important for the production of neurotransmitters that function in the brain. The enzyme phenylalanine hydroxylase (PAH) is responsible for enabling the phenylalanine to tyrosine conversion to take place.

Individuals with phenylketonuria have a genetic defect in the ability to produce PAH, therefore the phenylalanine they get from their diet keeps accumulating rather than being converted to tyrosine. The two major consequences are: (1) toxic levels of phenylalanine in the body and (2) high ratio of phenylalanine to tyrosine associated with impairment of the production of neurotransmitters.

High levels of phenylalanine, as seen in untreated phenylketonuria, cause brain damage and associated mental retardation. Early implementation of a low phenylalanine diet prevents the mental retardation associated with this condition.










Phenylalanine/Tyrosine (Genova) result calculator

insert the value from you Phenylalanine/Tyrosine (Genova) test result.

What does it mean if your Phenylalanine/Tyrosine (Genova) result is too high?

Increased levels can potentially be used to diagnose phenylketonuria. If no inborn errors of metabolism (i.e. phenylketonuria) are present: Infections or inflammatory states often cause significant increases in serum phenylalanine and the phenylalanine-tyrosine ratio.


Are you concerned about your lab report?
Select your plan, upload your lab reports and we’ll provide you with a meaningful interpretation.

Basic Interpretation
  • Instant interpretation
  • Use self upload form
  • 1000+ biomarkers explained
  • Nutrition Recommendations
  • Cancel anytime
Full Interpretation
  • Instant interpretation
  • We upload 4 reports for you
  • 1000+ biomarkers explained
  • Nutrition Recommendations
  • Cancel anytime
  • Online support
Own It For Life
  • Unlimited access
  • No subscription
  • Instant interpretations
  • We upload 10 reports for you
  • 1000+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Test results don't lie. Learn what is happening inside your body.

Health is not exactly rocket science. You just have to know what your body needs and doesn't need. Your medical tests contain that information. Upload them to our service and we’ll help you understand, organize, and act on them.

Get Started

Medical results explained and interpreted. customer review

"I was really concerned about my lab results and my GP was not able to see me for another week. Through HealthMatters I was able to interpret my results instantly." thankfull female customer

"I've been keeping all my lab results in a spreadsheet, covering approximately 20 years. The HealthMatters team helped me upload that info into the cloud. I can show this data to my family and doctors now easily." thankful young female customer

"I had no idea what my lab results meant. Here I found all the biomarkers that I was looking for online. Finally, I have not only organized them all neatly in one place, but I am also grateful to be able to understand what they mean."

Privacy and security of personal data. HIPAA and GDPR compliant badges.

Your Privacy And Security

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put security measures in place to help protect against the loss, misuse or alteration of information under our control. We use procedural, physical and electronic security methods designed to prevent people who aren't authorized from getting access to this information. Our internal code of conduct adds additional privacy protection. See our Privacy Policy for more information.