Optimal Result: 0 - 0.3 µmol/L, or 0.00 - 0.03 µmol/dL.

Cystathionine is an intermediary metabolite that is formed in the sequential enzymatic conversion of methionine to cysteine. Cystathionine is normally detected at very low levels in plasma. It is found between homocysteine and cysteine and is formed by the enzyme cystathionine beta-synthase (CBS).

Serine and B-6 are required to produce cystathionine from homocysteine.
 

What does it mean if your Cystathionine (Plasma) result is too low?

– A defect in cystathionine beta-synthase (=CBS) may elevate homocysteine and decrease both cystathionine and cysteine levels.

– Cystathionine levels are normally very low, but a disproportionately low cystathionine level in the presence of elevated homocysteine may be interpreted as being indicative of compromised CBS activity.

– Lower levels are likely due to low B2 and maybe also B6. This will limit flow into the transsulfuration pathway, which could limit glutathione synthesis. The low cystathionine would be consistent with low methionine and could also be caused by low magnesium or low B6 availability as P5P, the latter of which could be caused by low B2.

– Subnormal cystathionine is usually a nutritional condition that is readily corrected by adequate provision of serine and B-6/P-5-P. If dietary cysteine intake is insufficient, there could also be a cysteine deficiency that could be associated with subnormal intracellular glutathione and decreased antioxidant and detoxification (chemical and heavy metal) capacity.

What does it mean if your Cystathionine (Plasma) result is too high?

There might be a B6 functional deficit as B6 or P-5-P is required for the conversion of cystathionine to cysteine. Hence low cysteine can result.

Understand blood, stool, and urine medical results from your labs.

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Get 10% off of your first yearly or monthly plan.

Use promocode

Essential Plan


  • Monthly subscription
  • Instant interpretation
  • Use the free self-upload form
  • Additional charge for upload service
  • 2000+ biomarkers explained
  • Recommendations
  • Cancel anytime

Advanced Plan


  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 2000+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium plan


  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 2000+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Healthmatters.io software for professional use.

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.

Learn More


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals
×

Understand Your Lab Result Now

  • Instant interpretation
  • 2000+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode:

;