Optimal Result: 0 - 0.22 Ratio.

Also known as: Alpha-Amino-N-Butyric Acid to Leucine ratio

Alcohol consumption can result in elevations of the plasma Alpha-ANB/Leucine ratio. But to see this biomarker as a conclusive marker for alcoholism is not proven. The increase in the plasma Alpha-ANB/Leucine ratio does not appear to be specific for alcoholism because it was found elevated in nonalcoholic liver disease.

It is most likely that the rise in the plasma Alpha-ANB/Leucine ratio identifies a subgroup of alcoholics. What determines this subgroup of alcoholics remains unclear, but it could be the quantity of alcohol intake, a nutritional deficiency, or the presence of liver disease.

References:

  • Plasma alpha-amino-n-butyric acid/leucine ratio in alcoholics. (L)
  • On the clinical significance of the plasma alpha-amino-n-butyric acid:leucine ratio. (L)
  • Plasma alpha amino-n-butyric acid to leucine ratio: an empirical biochemical marker of alcoholism (L)
  • Ratio of plasma α-amino-n-butyric acid to leucine in alcoholism (L)

What does it mean if your Alpha-ANB/Leucine result is too high?

The Alpha-ANB/Leucine ratio can be a marker for alcoholism. Elevations of this amino acid are seen in some alcoholics, but it does not appear to be specific for alcoholism because it was found elevated in nonalcoholic liver disease.

Elevated plasma Alpha-Amino-N-Butyric Acid indicates vitamin B6 insufficiency since this amino acid is metabolized via the usual hepatic transamination reaction requiring pyridoxal phosphate. 

In a study the Alpha-ANB/Leucine ratio was also elevated in children with Reye’s syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency. The results indicate that an elevated ratio is not specific for adults with alcoholic liver injury and that the ratio may be high even without the presence of clinically apparent hepatic disease. An altered ratio may reflect the presence of an inherent metabolic defect.

Understand blood, stool, and urine medical results from your labs.

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Get 10% off of your first yearly or monthly plan.

Use promocode

Essential Plan


  • Monthly subscription
  • Instant interpretation
  • Use the free self-upload form
  • Additional charge for upload service
  • 2000+ biomarkers explained
  • Recommendations
  • Cancel anytime

Advanced Plan


  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 2000+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium plan


  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 2000+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Healthmatters.io software for professional use.

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.

Learn More


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals
×

Understand Your Lab Result Now

  • Instant interpretation
  • 2000+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode:

;