The Hydroxyproline to Proline Ratio describes the relationship between Proline and Hydroxyproline and can be looked at in relation to your collagen metabolism.
What is Hydroxyproline?
Hydroxyproline is a collagen related amino acid. Hydroxyproline is a nonessential amino acid, which means that it is manufactured from other amino acids in the liver. Hydroxyproline is necessary for the construction of the body’s major structural protein, collagen. Hydroxyproline is present in essentially all tissues and all genetic types of collagen.
Defects in collagen synthesis lead to easy bruising, internal bleeding, breakdown of connective tissue of the ligaments and tendons, and increased risk to blood vessel damage.
Hydroxyproline’s immediate precursor is proline. The conversion of proline to hydroxyproline requires vitamin C (ascorbic acid). Vitamin C deficiency results in the poor conversion of proline to hydroxyproline.
What is Proline?
Proline is a nonessential amino acid, which means that it is manufactured from other amino acids in the liver; it does not have to be obtained directly through the diet.
Proline is the precursor to hydroxyproline, which is a major amino acid found in the connective tissue of the body – collagen.
Vitamin C deficiency decreases the conversion of proline to hydroxyproline, which leads to reduced collagen stability. In this case your proline is relatively high compared to your hydroxyproline
Increased hydroxyproline levels in the urine and/or serum are normally associated with degradation of connective tissue.
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