Genova: Complete Hormones (24hr)

Pregnanediol (24hr urine)

Optimal Result: 0.3 - 4.2 micromol/24 hr.

Progesterone rapidly metabolizes by the time it reaches the urine, and its direct metabolite, pregnanediol, is a reflection of circulating progesterone concentrations.

Progesterone is important for normal reproductive and menstrual function, and influences the health of bone, blood vessels, heart, brain, skin, and many other tissues and organs.

As a precursor, progesterone is used by the body to make other steroid hormones, including DHEA, cortisol, estrogen and testosterone. 

In addition, progesterone plays an important role in mood, blood sugar balance, libido, and thyroid function, as well as adrenal gland health. 

Where is progesterone produced?

Progesterone is primarily produced in the ovaries in premenopausal women and in the adrenal cortex in postmenopausal women. Although progesterone is found in both women and men, the physiological role in men is poorly understood at this point.

What does it mean if your Pregnanediol (24hr urine) result is too low?

In women, lower levels of progesterone have been associated with dysfunctional uterine bleeding, and may play a role in osteoporosis and impaired neurological function.

The clinical significance of low levels of progesterone in men is poorly understood. Low progesterone levels may be involved in male infertility.

What does it mean if your Pregnanediol (24hr urine) result is too high?

Excessive amounts of progesterone in women can result in problems such as dysglycemia (=a broad term that refers to an abnormality in blood sugar stability), alopecia (=hair loss or baldness), acne, and breast tenderness

The clinical significance of high levels of progesterone in men is poorly understood. Increased levels of progesterone have been found in states of stress and anxiety in men and women: this may relate to its sedative or stress-countering effects. 

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