Estrone is the predominant estrogen in post-menopausal women and inter-converts with estradiol. This conversion is dependant on the bidirectional activity of 17-beta-hydroxysteroid dehydrogenase, which also converts testosterone to androstenedione (an intermediate of androsterone, etiocholanolone, and estrone).
Why does estrogen decrease?
- Age (peri-menopause and menopause)
- Irregular cycles/skipped cycles/anovulation
- Hysterectomy with ovaries removed
- Anorexia
- Low cholesterol (backbone to hormones)
- Extreme exercise or training
- Extreme stress resulting in skipped menses
- Under appropriate body weight percentage for height/age
• Mixed research: suggested <15% body fat = amenorrhea
- Hypogonadism (ovaries fail)
- Hypopituitarism (pituitary not communicating)
- Decreased blood flow to the ovaries
- Ex. Surgery or smokers
- Breast feeding
- Hypothyroidism
- PCOS
- Fertility medications
- Opioid pain medications (in last 6 months)
- Hormonal birth control – pill, patch, ring, implant, injection
Why do Estrogen levels increase?
1. Overweight/obesity
2. Peri-menopause = surges of estrogen
3. Diabetes
4. PCOS
5. Estrogen supplementation
6. Steroid medications
7. Poor liver clearance so estrogens build up
8. Dysbiosis/Estrobolome problems
9. Over aromatization from testosterone
10. Environmental estrogens (difficult to test however)
11. Alcohol (2 or more glasses/day shown to increase E)
12. Ovarian cysts
$79 per year
$6.60 per month billed annually
Use promocode
$79 per year
$250 single payment
$45 per month
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.
Learn MoreAt HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
11-Hydroxy-androsterone (24hr urine), 11-Hydroxy-androsterone (FMV urine), 11-Hydroxy-etiocholanolone (24hr urine), 11-Hydroxy-etiocholanolone (FMV urine), 11-Keto-androsterone (24hr urine), 11-Keto-androsterone (FMV urine), 11-Keto-etiocholanolone (24hr urine), 11-Keto-etiocholanolone (FMV urine), 11b-HSD Index (FMV urine), 16a-Hydroxyestrone (16a-OH E1), 16a-Hydroxyestrone (FMV urine), 17-Hydroxysteroids, Total, 17-Hydroxysteroids, Total (24hr urine), 17-Ketosteroids Total (FMV urine), 17-Ketosteroids, Total (24hr urine), 2-Hydroxyestrone (FMV urine), 2-Hydroxyestrone + 2-Hydroxyestradiol [2-OH(E1+E2)], 2-Hydroxyestrone/16a-Hydroxyestrone Ratio (FMV urine), 2-Methoxyestrone (FMV urine), 2-Methoxyestrone+2-Methoxyestradiol [2MeO(E1+E2)], 2-Methoxyestrone/2-Hydroxyestrone Ratio, 2-OH(E1+E2) / 16a-OHE1, 2-OH(E1+E2) / 2-MeO(E1+E2), 4-Hydroxyestrone (FMV urine), 4-Hydroxyestrone+4-Hydroxyestradiol [4-OH(E1+E2)], 4-Methoxyestrone (FMV urine), 4-Methoxyestrone+4-Methoxyestradiol [4MeO(E1+E2)], 5a-Reductase Activity (Etiocholanolone/Androsterone Ratio), allo-Tetrahydrocortisol, a-THF (24hr urine), allo-Tetrahydrocortisol, a-THF (FMV urine), Anabolic/Catabolic Balance (24hr urine), Anabolic/Catabolic Balance (FMV), Androstanediol (24hr urine), Androstanediol (FMV urine), Androsterone (24hr urine), Androsterone (FMV urine), Cortisol, Free (FMV urine), DHEA (24hr urine), DHEA (FMV urine), E/A: 5b/5a Ratio (24hr urine), E/A: 5b/5a Ratio (FMV urine), Estradiol (E2) (24hr), Estradiol (E2) - Premenopause (luteal), Estriol (E3) (24hr), Estriol (E3) - Premenopause (luteal), Estrone (E1) (24hr), Estrone (E1) - Premenopause (luteal), Etiocholanolone (24hr urine), Etiocholanolone (FMV urine), Pregnanediol (24hr urine), Pregnanediol (FMV urine), Pregnanetriol (24hr urine), Pregnanetriol (FMV urine), Testosterone (24hr urine), Testosterone (FMV urine), Tetrahydrocortisol, THF (24hr urine), Tetrahydrocortisol, THF (FMV urine), Tetrahydrocortisone, THE (24hr urine), Tetrahydrocortisone, THE (FMV urine), Tetrahydrodeoxycortisol (FMV urine), Tetrahydrodeoxycortisol, THS (24hr urine), Triiodothyronine, T3 (FMV urine)