A healthy result should fall into the range 2 - 26.2 mcg/g Creat..
Estrone is the predominant estrogen in post-menopausal women and inter-converts with estradiol. This conversion is dependant on the bidirectional activity of 17-beta-hydroxysteroid dehydrogenase, which also converts testosterone to androstenedione (an intermediate of androsterone, etiocholanolone, and estrone).
insert the value from you Estrone (E1) - Premenopause (luteal) test result.
Why does estrogen decrease?
- Age (peri-menopause and menopause)
- Irregular cycles/skipped cycles/anovulation
- Hysterectomy with ovaries removed
- Anorexia
- Low cholesterol (backbone to hormones)
- Extreme exercise or training
- Extreme stress resulting in skipped menses
- Under appropriate body weight percentage for height/age
• Mixed research: suggested <15% body fat = amenorrhea
- Hypogonadism (ovaries fail)
- Hypopituitarism (pituitary not communicating)
- Decreased blood flow to the ovaries
- Ex. Surgery or smokers
- Breast feeding
- Hypothyroidism
- PCOS
- Fertility medications
- Opioid pain medications (in last 6 months)
- Hormonal birth control – pill, patch, ring, implant, injection
Why do Estrogen levels increase?
1. Overweight/obesity
2. Peri-menopause = surges of estrogen
3. Diabetes
4. PCOS
5. Estrogen supplementation
6. Steroid medications
7. Poor liver clearance so estrogens build up
8. Dysbiosis/Estrobolome problems
9. Over aromatization from testosterone
10. Environmental estrogens (difficult to test however)
11. Alcohol (2 or more glasses/day shown to increase E)
12. Ovarian cysts
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11-Hydroxy-androsterone (24hr urine), 11-Hydroxy-etiocholanolone (24hr urine), 11-Keto-androsterone (24hr urine), 11-Keto-etiocholanolone (24hr urine), 16a-Hydroxyestrone (16a-OH E1) - Premenopause (luteal), 17-Hydroxysteroids, Total (24hr urine), 17-Ketosteroids, Total (24hr urine), 2-Hydroxyestrone + 2-Hydroxyestradiol [2-OH(E1+E2)] - Premenopause (luteal), 2-Methoxyestrone+2-Methoxyestradiol [2MeO(E1+E2)] - Premenopause (luteal), 2-OH(E1+E2) / 16a-OHE1 - Premenopause (luteal), 2-OH(E1+E2) / 2-MeO(E1+E2) - Premenopause (luteal), 4-Hydroxyestrone+4-Hydroxyestradiol [4-OH(E1+E2)] - Premenopause (luteal), 4-Methoxyestrone+4-Methoxyestradiol [4MeO(E1+E2)] - Premenopause (luteal), allo-Tetrahydrocortisol, a-THF (24hr urine), Anabolic/Catabolic Balance (24hr urine), Androstanediol (24hr urine), Androsterone (24hr urine), DHEA (24hr urine), E/A: 5b/5a Ratio (24hr urine), Estradiol (E2) - Premenopause (luteal), Estriol (E3) - Premenopause (luteal), Estrone (E1) - Premenopause (luteal), Etiocholanolone (24hr urine), Pregnanediol (24hr urine), Pregnanetriol (24hr urine), Testosterone (24hr urine), Tetrahydrocortisol, THF (24hr urine), Tetrahydrocortisone, THE (24hr urine), Tetrahydrodeoxycortisol, THS (24hr urine)
